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Protein

Argininosuccinate synthase

Gene

argG

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei87 – 871CitrullineUniRule annotation
Binding sitei92 – 921CitrullineUniRule annotation
Binding sitei117 – 1171ATP; via amide nitrogenUniRule annotation
Binding sitei119 – 1191AspartateUniRule annotation
Binding sitei123 – 1231AspartateUniRule annotation
Binding sitei123 – 1231CitrullineUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei127 – 1271CitrullineUniRule annotation
Binding sitei176 – 1761CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei261 – 2611CitrullineUniRule annotation
Binding sitei273 – 2731CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDDES546414:GHOM-80-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Deide_00720
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Argininosuccinate synthasePRO_1000201678Add
BLAST

Proteomic databases

PaxDbiC1CXR6.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi546414.Deide_00720.

Structurei

3D structure databases

ProteinModelPortaliC1CXR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CXR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDKIVLAY SGGLDTSIIL KWLQTERNYD VVCFTADLGQ GDEVEEARVK
60 70 80 90 100
ALNTGAVAAY ALDLREEFVR DYVFPMFRSS ALYEGYYLLG TSIARPLIAK
110 120 130 140 150
KMVEIAQKEG AVAVSHGATG KGNDQVRFEM TAYALQPDIV TVAPWRDWEF
160 170 180 190 200
QGRADLEAFA HEHGIPVPTT KKDPWSTDAN MLHISYEGGI LEDPWAEPPA
210 220 230 240 250
HMFKLTVAPE EAPDEAEYVE IEFLNGDAVA INGETLSPAA LLDRANEIGG
260 270 280 290 300
RHGVGRVDLV ENRFVGMKSR GVYETPGGTL LYHARRAVES LTLDREVLHQ
310 320 330 340 350
RDALGPKYAE LVYNGFWFAP EREALQVYMD HVAKAVTGTA RLKLYKGNCI
360 370 380 390 400
VAGRKAERSL YDKDLVSFEA GGDYNQHDAG AFIKLNALRM RVQARVEAKA

GQKDKAGD
Length:408
Mass (Da):45,133
Last modified:May 25, 2009 - v1
Checksum:iC79786C440520B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO44872.1.
RefSeqiYP_002784626.1. NC_012526.1.

Genome annotation databases

EnsemblBacteriaiACO44872; ACO44872; Deide_00720.
KEGGiddr:Deide_00720.
PATRICi21613506. VBIDeiDes121019_0075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO44872.1.
RefSeqiYP_002784626.1. NC_012526.1.

3D structure databases

ProteinModelPortaliC1CXR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi546414.Deide_00720.

Proteomic databases

PaxDbiC1CXR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO44872; ACO44872; Deide_00720.
KEGGiddr:Deide_00720.
PATRICi21613506. VBIDeiDes121019_0075.

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciDDES546414:GHOM-80-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiASSY_DEIDV
AccessioniPrimary (citable) accession number: C1CXR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2009
Last sequence update: May 25, 2009
Last modified: March 31, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.