C1CXL8 (C1CXL8_DEIDV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
Short name=CMK HAMAP MF_00061
EC=2.7.1.148 HAMAP MF_00061

Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP MF_00061

Gene names

Name:	ispE HAMAP MF_00061
Ordered Locus Names:	Deide_00260 EMBL ACO44824.2

Organism

Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]

Taxonomic identifier

546414 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061
Catalytic activity	ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061
Sequence similarities	Belongs to the GHMP kinase family. IspE subfamily. HAMAP MF_00061

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00061
Ligand	ATP-binding RuleBase RU003563 HAMAP MF_00061 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 HAMAP MF_00061 EMBL ACO44824.2 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	90 – 100	11	ATP By similarity HAMAP MF_00061
Sites
	Active site	8	1	By similarity HAMAP MF_00061
	Active site	129	1	By similarity HAMAP MF_00061

Sequences

	Sequence		Length	Mass (Da)
	C1CXL8 [UniParc]. Last modified March 8, 2011. Version 2. Checksum: 35961C4A65A832EE	FASTA	275	28,781
	10 20 30 40 50 60 MQVFAPAKIN LGLSVLGVRS DGYHDLHSLM VPLATGDELE LEPASELSLR VLGADLPCDS 70 80 90 100 110 120 RNLVYRAAHA YLDAAGMARG AAITLHKQLP LASGLGGGSS DAASTLRALH EMYPADVDLP 130 140 150 160 170 180 GLALRLGADV PFFLLGSAAI AEGVGERLSP VQTGPLSLVL LNPGVEVSAR EAYLWLDETG 190 200 210 220 230 240 AFTSELDVQA IVQGLAAGSE EVPYFNALQP AVVARHPLIQ VALDALRDAG LHAPLMSGSG 250 260 270 STCFALAQDA MHADRAAQVL AARYPDWWIQ ATSTQ

References

[1]

"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti." de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J. PLoS Genet. 5:E1000434-E1000434(2009) [PubMed: 19370165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001114 Genomic DNA. Translation: ACO44824.2.
RefSeq	YP_002784578.2. NC_012526.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1CXL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7739125.
GenomeReviews	Gene locus Deide_00260 in contig CP001114_GR.
KEGG	ddr:Deide_00260.
PATRIC	21613402. VBIDeiDes121019_0026.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00061. IspE. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00919.
PANTHER	PTHR20861:SF2. IspE. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF010376. IspE. 1 hit.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00154. IspE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1CXL8_DEIDV

Accession

Primary (citable) accession number: C1CXL8

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	March 8, 2011
Last modified:	January 25, 2012
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)