C1CXH0 (EFG_DEIDV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	Deide_18990

Organism

Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]

Taxonomic identifier

546414 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	697 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 697	697	Elongation factor G HAMAP MF_00054_B		PRO_1000202298
Regions
	Nucleotide binding	19 – 26	8	GTP By similarity
	Nucleotide binding	89 – 93	5	GTP By similarity
	Nucleotide binding	143 – 146	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1CXH0 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 97CBE039BC3E3D33	FASTA	697	76,634
	10 20 30 40 50 60 MTTKAQSYLT HFRNIGIAAH IDAGKTTTTE RILYYTGRTH NIGEVHDGAA TMDWMEQERE 70 80 90 100 110 120 RGITITAAAT TAKWKRSGTD QEYVVNIIDT PGHVDFTIEV ERSMRVLDGA VAVFDSSQGV 130 140 150 160 170 180 EPQSETVWRQ ADRYGVPRIA FSNKMDKTGA SFELVLTDIK ERLGAIPAPI QYPMGQENDF 190 200 210 220 230 240 KGIIDIVRMR AHVYTNDLGT DIVESDIPAE FADKVAEMRA QLIEAAAEVD EDLMMMYLEG 250 260 270 280 290 300 EEPSVEQLVS AIRKGTIEKK IFPVLCGSAL KNKGVQLLLD AVVDYLPSPL EVPAIRGKVE 310 320 330 340 350 360 DSEDTVEFPA DPEGKLAALA FKIMADPYVG RLTFVRIYSG TLQSGSYVYN ASKDKRDRVG 370 380 390 400 410 420 RLLKMHANSR EEVTELRAGE LGAVIGLKDA GTGNTLIADG EDRVLLESID VPEPVIKLAI 430 440 450 460 470 480 EPKTKADQEK MGIGLQKLAE EDPTFRVESD QESGQTTISG MGELHLEILV DRLKREYKVE 490 500 510 520 530 540 ANVGAPQVAY RETITKAVDV EGKFVRQSGG RGQFGHVKIK AEPLEPGAGF VFENIVVGGT 550 560 570 580 590 600 VPREFIGPAQ KGIEEALQSG PMLGFPVVDM KVSLYDGSYH EVDSSEMAFK IAGSMALKEA 610 620 630 640 650 660 VQKGAPAILE PIMRVEVTVP EDYMGDIIGD LNSRRGQIQG MEARGNAQIV KAFVPLSEMF 670 680 690 GYATDMRSMT QGRASYSMFF DHYSQVPNNL AQQLMKK

References

[1]

"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti." de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J. PLoS Genet. 5:E1000434-E1000434(2009) [PubMed: 19370165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001114 Genomic DNA. Translation: ACO46887.1.
RefSeq	YP_002786641.1. NC_012526.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1CXH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7737597.
GenomeReviews	Gene locus Deide_18990 in contig CP001114_GR.
KEGG	ddr:Deide_18990.
PATRIC	21617794. VBIDeiDes121019_2172.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CNEWREK.
ProtClustDB	PRK00007.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_DEIDV

Accession

Primary (citable) accession number: C1CXH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program