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C1CXB5

- PNP_DEIDV

UniProt

C1CXB5 - PNP_DEIDV

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Deide_18440
Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901Magnesium By similarity
Metal bindingi496 – 4961Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDDES546414:GHOM-2090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Deide_18440
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000381881Add
BLAST

Proteomic databases

PaxDbiC1CXB5.

Interactioni

Protein-protein interaction databases

STRINGi546414.Deide_18440.

Structurei

3D structure databases

ProteinModelPortaliC1CXB5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 62367KH
Add
BLAST
Domaini625 – 69369S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CXB5-1 [UniParc]FASTAAdd to Basket

« Hide

MIGKTYTTML GGRELSIETG RLAKLVSGSV TLRYGDTMLL VTAQAREEKS    50
PLDFLPLTVE FEERHYAVGK IPGSFHRREG RPGEKAILSA RITDRQLRPL 100
FPKGYRHETQ VIITVLSADQ QNAPDVLGPI GASAALSISD IPWGGPTACV 150
RVGQVDGQFI VNPTADQLTR SRMDLVVAGT RDAVMMVEAG AQTVSEEDLV 200
SAIEFAHAEM QGVIDLIERM RAEVGQEKFN FLAEGDLTQD LVPELAEKAR 250
AGGIRDALLT TKKKERSART KAVRDAIIAG YVPDPNAEGA AARIASLKDA 300
YAKVEKQELR RLILEEDLRA DGRNGRAVRP IWIEARPLPR AHGSAIFTRG 350
ETQVLGVATL GTERDEILVD DLTTEDNDKF MLHYNFPPYS TGEVKRMGGQ 400
SRREIGHGHL AKRAIRAVLP SFEEFPYVIR LVGEVLESNG SSSMATVCAG 450
VLALMDAGVP IKAPVAGVAM GLVMEGDKYR VLTDILGLED ALGDMDFKVC 500
GTAEGVTALQ MDIKVGGITP QVMREALAQA REGRLHILGK MAEVLSSPRP 550
ELSPTAPRII SIKINPELIG KVIGPGGKQV RELEAMGAQV TIEEDGTIRV 600
FSADGAAAEA VRARIAGLTK EAKVGEEYEG TVVKTAPFGA FVNLYAGQDG 650
MLHISQISEE RLSAVEDALN VGDKLRVKIA GIDDRGKIDL IRPELEGKIA 700
PREPRAPRGG GDRGPRPPRR D 721
Length:721
Mass (Da):77,919
Last modified:May 26, 2009 - v1
Checksum:iAB1614F5ACC1181C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001114 Genomic DNA. Translation: ACO46832.1.
RefSeqiWP_012693954.1. NC_012526.1.
YP_002786586.1. NC_012526.1.

Genome annotation databases

EnsemblBacteriaiACO46832; ACO46832; Deide_18440.
GeneIDi7737542.
KEGGiddr:Deide_18440.
PATRICi21617682. VBIDeiDes121019_2116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001114 Genomic DNA. Translation: ACO46832.1 .
RefSeqi WP_012693954.1. NC_012526.1.
YP_002786586.1. NC_012526.1.

3D structure databases

ProteinModelPortali C1CXB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_18440.

Proteomic databases

PaxDbi C1CXB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO46832 ; ACO46832 ; Deide_18440 .
GeneIDi 7737542.
KEGGi ddr:Deide_18440.
PATRICi 21617682. VBIDeiDes121019_2116.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DDES546414:GHOM-2090-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiPNP_DEIDV
AccessioniPrimary (citable) accession number: C1CXB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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