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C1CXB5

- PNP_DEIDV

UniProt

C1CXB5 - PNP_DEIDV

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi490 – 4901MagnesiumUniRule annotation
Metal bindingi496 – 4961MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDDES546414:GHOM-2090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Deide_18440
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Polyribonucleotide nucleotidyltransferasePRO_0000381881Add
BLAST

Proteomic databases

PaxDbiC1CXB5.

Interactioni

Protein-protein interaction databases

STRINGi546414.Deide_18440.

Structurei

3D structure databases

ProteinModelPortaliC1CXB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini557 – 62367KHUniRule annotationAdd
BLAST
Domaini625 – 69369S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CXB5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGKTYTTML GGRELSIETG RLAKLVSGSV TLRYGDTMLL VTAQAREEKS
60 70 80 90 100
PLDFLPLTVE FEERHYAVGK IPGSFHRREG RPGEKAILSA RITDRQLRPL
110 120 130 140 150
FPKGYRHETQ VIITVLSADQ QNAPDVLGPI GASAALSISD IPWGGPTACV
160 170 180 190 200
RVGQVDGQFI VNPTADQLTR SRMDLVVAGT RDAVMMVEAG AQTVSEEDLV
210 220 230 240 250
SAIEFAHAEM QGVIDLIERM RAEVGQEKFN FLAEGDLTQD LVPELAEKAR
260 270 280 290 300
AGGIRDALLT TKKKERSART KAVRDAIIAG YVPDPNAEGA AARIASLKDA
310 320 330 340 350
YAKVEKQELR RLILEEDLRA DGRNGRAVRP IWIEARPLPR AHGSAIFTRG
360 370 380 390 400
ETQVLGVATL GTERDEILVD DLTTEDNDKF MLHYNFPPYS TGEVKRMGGQ
410 420 430 440 450
SRREIGHGHL AKRAIRAVLP SFEEFPYVIR LVGEVLESNG SSSMATVCAG
460 470 480 490 500
VLALMDAGVP IKAPVAGVAM GLVMEGDKYR VLTDILGLED ALGDMDFKVC
510 520 530 540 550
GTAEGVTALQ MDIKVGGITP QVMREALAQA REGRLHILGK MAEVLSSPRP
560 570 580 590 600
ELSPTAPRII SIKINPELIG KVIGPGGKQV RELEAMGAQV TIEEDGTIRV
610 620 630 640 650
FSADGAAAEA VRARIAGLTK EAKVGEEYEG TVVKTAPFGA FVNLYAGQDG
660 670 680 690 700
MLHISQISEE RLSAVEDALN VGDKLRVKIA GIDDRGKIDL IRPELEGKIA
710 720
PREPRAPRGG GDRGPRPPRR D
Length:721
Mass (Da):77,919
Last modified:May 26, 2009 - v1
Checksum:iAB1614F5ACC1181C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO46832.1.
RefSeqiWP_012693954.1. NC_012526.1.
YP_002786586.1. NC_012526.1.

Genome annotation databases

EnsemblBacteriaiACO46832; ACO46832; Deide_18440.
GeneIDi7737542.
KEGGiddr:Deide_18440.
PATRICi21617682. VBIDeiDes121019_2116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO46832.1 .
RefSeqi WP_012693954.1. NC_012526.1.
YP_002786586.1. NC_012526.1.

3D structure databases

ProteinModelPortali C1CXB5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_18440.

Proteomic databases

PaxDbi C1CXB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO46832 ; ACO46832 ; Deide_18440 .
GeneIDi 7737542.
KEGGi ddr:Deide_18440.
PATRICi 21617682. VBIDeiDes121019_2116.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DDES546414:GHOM-2090-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiPNP_DEIDV
AccessioniPrimary (citable) accession number: C1CXB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3