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C1CXB5

- PNP_DEIDV

UniProt

C1CXB5 - PNP_DEIDV

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi490 – 4901MagnesiumUniRule annotation
    Metal bindingi496 – 4961MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciDDES546414:GHOM-2090-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Deide_18440
    OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
    Taxonomic identifieri546414 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002208: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Polyribonucleotide nucleotidyltransferasePRO_0000381881Add
    BLAST

    Proteomic databases

    PaxDbiC1CXB5.

    Interactioni

    Protein-protein interaction databases

    STRINGi546414.Deide_18440.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CXB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini557 – 62367KHUniRule annotationAdd
    BLAST
    Domaini625 – 69369S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CXB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGKTYTTML GGRELSIETG RLAKLVSGSV TLRYGDTMLL VTAQAREEKS    50
    PLDFLPLTVE FEERHYAVGK IPGSFHRREG RPGEKAILSA RITDRQLRPL 100
    FPKGYRHETQ VIITVLSADQ QNAPDVLGPI GASAALSISD IPWGGPTACV 150
    RVGQVDGQFI VNPTADQLTR SRMDLVVAGT RDAVMMVEAG AQTVSEEDLV 200
    SAIEFAHAEM QGVIDLIERM RAEVGQEKFN FLAEGDLTQD LVPELAEKAR 250
    AGGIRDALLT TKKKERSART KAVRDAIIAG YVPDPNAEGA AARIASLKDA 300
    YAKVEKQELR RLILEEDLRA DGRNGRAVRP IWIEARPLPR AHGSAIFTRG 350
    ETQVLGVATL GTERDEILVD DLTTEDNDKF MLHYNFPPYS TGEVKRMGGQ 400
    SRREIGHGHL AKRAIRAVLP SFEEFPYVIR LVGEVLESNG SSSMATVCAG 450
    VLALMDAGVP IKAPVAGVAM GLVMEGDKYR VLTDILGLED ALGDMDFKVC 500
    GTAEGVTALQ MDIKVGGITP QVMREALAQA REGRLHILGK MAEVLSSPRP 550
    ELSPTAPRII SIKINPELIG KVIGPGGKQV RELEAMGAQV TIEEDGTIRV 600
    FSADGAAAEA VRARIAGLTK EAKVGEEYEG TVVKTAPFGA FVNLYAGQDG 650
    MLHISQISEE RLSAVEDALN VGDKLRVKIA GIDDRGKIDL IRPELEGKIA 700
    PREPRAPRGG GDRGPRPPRR D 721
    Length:721
    Mass (Da):77,919
    Last modified:May 26, 2009 - v1
    Checksum:iAB1614F5ACC1181C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO46832.1.
    RefSeqiWP_012693954.1. NC_012526.1.
    YP_002786586.1. NC_012526.1.

    Genome annotation databases

    EnsemblBacteriaiACO46832; ACO46832; Deide_18440.
    GeneIDi7737542.
    KEGGiddr:Deide_18440.
    PATRICi21617682. VBIDeiDes121019_2116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO46832.1 .
    RefSeqi WP_012693954.1. NC_012526.1.
    YP_002786586.1. NC_012526.1.

    3D structure databases

    ProteinModelPortali C1CXB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 546414.Deide_18440.

    Proteomic databases

    PaxDbi C1CXB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO46832 ; ACO46832 ; Deide_18440 .
    GeneIDi 7737542.
    KEGGi ddr:Deide_18440.
    PATRICi 21617682. VBIDeiDes121019_2116.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci DDES546414:GHOM-2090-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VCD115 / DSM 17065 / LMG 22923.

    Entry informationi

    Entry nameiPNP_DEIDV
    AccessioniPrimary (citable) accession number: C1CXB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3