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C1CWI8

- GSA_DEIDV

UniProt

C1CWI8 - GSA_DEIDV

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDDES546414:GHOM-1810-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Deide_15910
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiC1CWI8.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi546414.Deide_15910.

Structurei

3D structure databases

ProteinModelPortaliC1CWI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTVIGHAN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CWI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSTTTRSE ALFERARAVT PGGVNSPVRA FKSVGGVPRF IREAHGAYLT
60 70 80 90 100
DMDDTRYVDY IGSWGPMILG HDHPTIREAI ATALTGGTSF GAPGEREVEL
110 120 130 140 150
AELVTRLTGA GRVRFVNSGT EATMSALRLA RGFTGRKFIV KFRGNYHGHA
160 170 180 190 200
DGLLVEAGSG LLTNAEGVLG SAAPSSAGVP EEYASLTLVS EYNDPAALDA
210 220 230 240 250
LMRLRGHEVA AVIFEPVVGN AGVLVPTPDF LEALHRVKAS GALLVADEVM
260 270 280 290 300
TGFRLSLNGA TGLLGLEPDL TCWGKIIGGG LPVGAYGGRA DVMDFVSPQG
310 320 330 340 350
PVYQAGTLSG NPLAMAAGLA TLQTLEADPG IYGRLEAYTA ALASGLRAAA
360 370 380 390 400
DEAGVPVSIN RVGSMLTAFH QDVPDGSIRT YADAARSDTT GFATWFQGML
410 420 430 440
ARGVYWAPSQ FESIFVSGAH TDRELNVTLE AARSAYGGTP V
Length:441
Mass (Da):46,023
Last modified:May 26, 2009 - v1
Checksum:i9C8DFC10F064CD60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO46555.1.
RefSeqiYP_002786309.1. NC_012526.1.

Genome annotation databases

EnsemblBacteriaiACO46555; ACO46555; Deide_15910.
GeneIDi7737262.
KEGGiddr:Deide_15910.
PATRICi21617108. VBIDeiDes121019_1832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001114 Genomic DNA. Translation: ACO46555.1 .
RefSeqi YP_002786309.1. NC_012526.1.

3D structure databases

ProteinModelPortali C1CWI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_15910.

Proteomic databases

PaxDbi C1CWI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO46555 ; ACO46555 ; Deide_15910 .
GeneIDi 7737262.
KEGGi ddr:Deide_15910.
PATRICi 21617108. VBIDeiDes121019_1832.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi TVIGHAN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci DDES546414:GHOM-1810-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiGSA_DEIDV
AccessioniPrimary (citable) accession number: C1CWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3