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C1CWI8

- GSA_DEIDV

UniProt

C1CWI8 - GSA_DEIDV

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDDES546414:GHOM-1810-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:Deide_15910
    OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
    Taxonomic identifieri546414 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002208: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PaxDbiC1CWI8.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi546414.Deide_15910.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CWI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiTVIGHAN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CWI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSTTTRSE ALFERARAVT PGGVNSPVRA FKSVGGVPRF IREAHGAYLT    50
    DMDDTRYVDY IGSWGPMILG HDHPTIREAI ATALTGGTSF GAPGEREVEL 100
    AELVTRLTGA GRVRFVNSGT EATMSALRLA RGFTGRKFIV KFRGNYHGHA 150
    DGLLVEAGSG LLTNAEGVLG SAAPSSAGVP EEYASLTLVS EYNDPAALDA 200
    LMRLRGHEVA AVIFEPVVGN AGVLVPTPDF LEALHRVKAS GALLVADEVM 250
    TGFRLSLNGA TGLLGLEPDL TCWGKIIGGG LPVGAYGGRA DVMDFVSPQG 300
    PVYQAGTLSG NPLAMAAGLA TLQTLEADPG IYGRLEAYTA ALASGLRAAA 350
    DEAGVPVSIN RVGSMLTAFH QDVPDGSIRT YADAARSDTT GFATWFQGML 400
    ARGVYWAPSQ FESIFVSGAH TDRELNVTLE AARSAYGGTP V 441
    Length:441
    Mass (Da):46,023
    Last modified:May 26, 2009 - v1
    Checksum:i9C8DFC10F064CD60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO46555.1.
    RefSeqiWP_012693678.1. NC_012526.1.
    YP_002786309.1. NC_012526.1.

    Genome annotation databases

    EnsemblBacteriaiACO46555; ACO46555; Deide_15910.
    GeneIDi7737262.
    KEGGiddr:Deide_15910.
    PATRICi21617108. VBIDeiDes121019_1832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001114 Genomic DNA. Translation: ACO46555.1 .
    RefSeqi WP_012693678.1. NC_012526.1.
    YP_002786309.1. NC_012526.1.

    3D structure databases

    ProteinModelPortali C1CWI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 546414.Deide_15910.

    Proteomic databases

    PaxDbi C1CWI8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO46555 ; ACO46555 ; Deide_15910 .
    GeneIDi 7737262.
    KEGGi ddr:Deide_15910.
    PATRICi 21617108. VBIDeiDes121019_1832.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi TVIGHAN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci DDES546414:GHOM-1810-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VCD115 / DSM 17065 / LMG 22923.

    Entry informationi

    Entry nameiGSA_DEIDV
    AccessioniPrimary (citable) accession number: C1CWI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3