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C1CWI8

- GSA_DEIDV

UniProt

C1CWI8 - GSA_DEIDV

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, Deide_15910
Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDDES546414:GHOM-1810-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Deide_15910
OrganismiDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Taxonomic identifieri546414 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002208: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_0000382302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiC1CWI8.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi546414.Deide_15910.

Structurei

3D structure databases

ProteinModelPortaliC1CWI8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiTVIGHAN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CWI8-1 [UniParc]FASTAAdd to Basket

« Hide

MTSSTTTRSE ALFERARAVT PGGVNSPVRA FKSVGGVPRF IREAHGAYLT    50
DMDDTRYVDY IGSWGPMILG HDHPTIREAI ATALTGGTSF GAPGEREVEL 100
AELVTRLTGA GRVRFVNSGT EATMSALRLA RGFTGRKFIV KFRGNYHGHA 150
DGLLVEAGSG LLTNAEGVLG SAAPSSAGVP EEYASLTLVS EYNDPAALDA 200
LMRLRGHEVA AVIFEPVVGN AGVLVPTPDF LEALHRVKAS GALLVADEVM 250
TGFRLSLNGA TGLLGLEPDL TCWGKIIGGG LPVGAYGGRA DVMDFVSPQG 300
PVYQAGTLSG NPLAMAAGLA TLQTLEADPG IYGRLEAYTA ALASGLRAAA 350
DEAGVPVSIN RVGSMLTAFH QDVPDGSIRT YADAARSDTT GFATWFQGML 400
ARGVYWAPSQ FESIFVSGAH TDRELNVTLE AARSAYGGTP V 441
Length:441
Mass (Da):46,023
Last modified:May 26, 2009 - v1
Checksum:i9C8DFC10F064CD60
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001114 Genomic DNA. Translation: ACO46555.1.
RefSeqiWP_012693678.1. NC_012526.1.
YP_002786309.1. NC_012526.1.

Genome annotation databases

EnsemblBacteriaiACO46555; ACO46555; Deide_15910.
GeneIDi7737262.
KEGGiddr:Deide_15910.
PATRICi21617108. VBIDeiDes121019_1832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001114 Genomic DNA. Translation: ACO46555.1 .
RefSeqi WP_012693678.1. NC_012526.1.
YP_002786309.1. NC_012526.1.

3D structure databases

ProteinModelPortali C1CWI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 546414.Deide_15910.

Proteomic databases

PaxDbi C1CWI8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO46555 ; ACO46555 ; Deide_15910 .
GeneIDi 7737262.
KEGGi ddr:Deide_15910.
PATRICi 21617108. VBIDeiDes121019_1832.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi TVIGHAN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci DDES546414:GHOM-1810-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCD115 / DSM 17065 / LMG 22923.

Entry informationi

Entry nameiGSA_DEIDV
AccessioniPrimary (citable) accession number: C1CWI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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