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C1CVN6 (UPPP_DEIDV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Deide_13160
OrganismDeinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) [Complete proteome] [HAMAP]
Taxonomic identifier546414 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000213146

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane249 – 26921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C1CVN6 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 4151B3AF56E413C9

FASTA27529,621
        10         20         30         40         50         60 
MDWVYAIVYG IVEGITEFLP ISSTGHLILT GNLMGVPWSK EVKDAFEVVI QGGAILSVLV 

        70         80         90        100        110        120 
YYWRDFLKIR HLGHDRSQQT LWTGVLVATI PAVVLGLAFG DQIQAVLFKP SVVAWALIVG 

       130        140        150        160        170        180 
GVLMWLIESR RVQPQVHAIE TIGVRRSLLI GVLQCLALVW PGFSRSASSI LGGMALGLDR 

       190        200        210        220        230        240 
PTATKFSFYL GVPTLGGAAL LNLVKERELI FGEIGLLNVV LGAGVSFVVA YLAIGWLLKF 

       250        260        270 
VSTNNFKGFA VYRVAVGVLI LVLIATGVMS NGSLA 

« Hide

References

[1]"Alliance of proteomics and genomics to unravel the specificities of Sahara bacterium Deinococcus deserti."
de Groot A., Dulermo R., Ortet P., Blanchard L., Guerin P., Fernandez B., Vacherie B., Dossat C., Jolivet E., Siguier P., Chandler M., Barakat M., Dedieu A., Barbe V., Heulin T., Sommer S., Achouak W., Armengaud J.
PLoS Genet. 5:E1000434-E1000434(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VCD115 / DSM 17065 / LMG 22923.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001114 Genomic DNA. Translation: ACO46253.1.
RefSeqYP_002786007.1. NC_012526.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING546414.Deide_13160.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO46253; ACO46253; Deide_13160.
GeneID7738573.
KEGGddr:Deide_13160.
PATRIC21616480. VBIDeiDes121019_1519.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAPIVFDIY.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycDDES546414:GHOM-1506-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DEIDV
AccessionPrimary (citable) accession number: C1CVN6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families