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Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei335Proton acceptorUniRule annotation1
Metal bindingi335ManganeseUniRule annotation1
Active sitei359Proton acceptorUniRule annotation1
Metal bindingi359ManganeseUniRule annotation1
Metal bindingi525ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:SPT_2171
OrganismiStreptococcus pneumoniae (strain Taiwan19F-14)
Taxonomic identifieri487213 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

C1CU77:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001651011 – 588L-fucose isomeraseAdd BLAST588

Structurei

3D structure databases

ProteinModelPortaliC1CU77.
SMRiC1CU77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249674.
KOiK01818.
OMAiHAQKGLP.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiView protein in InterPro
IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
PfamiView protein in Pfam
PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

C1CU77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP
60 70 80 90 100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD
110 120 130 140 150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTAIP
160 170 180 190 200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG
210 220 230 240 250
MRNESVDMTE FTRRMDRGIY DPEEFERAMV WVKEHIKEGV DRNREDLILS
260 270 280 290 300
KEEKEKQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ
310 320 330 340 350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL
360 370 380 390 400
TNTPQIFADV RTYWSPEAVK RVTGHTLEGC AAAGFLHLIN SGSCTLDGTG
410 420 430 440 450
QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK
460 470 480 490 500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW
510 520 530 540 550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM
560 570 580
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
Length:588
Mass (Da):65,739
Last modified:May 26, 2009 - v1
Checksum:i04AD1B8F2E13E420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO22340.1.
RefSeqiWP_000614263.1. NC_012469.1.

Genome annotation databases

EnsemblBacteriaiACO22340; ACO22340; SPT_2171.
KEGGisnt:SPT_2171.

Similar proteinsi

Entry informationi

Entry nameiFUCI_STRZT
AccessioniPrimary (citable) accession number: C1CU77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 25, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families