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Protein

Pseudouridine synthase

Gene

SPT_1270

Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil.UniRule annotation

Catalytic activityi

RNA uridine = RNA pseudouridine.UniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: InterPro

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Enzyme and pathway databases

BioCyciSPNE487213:GI07-1235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine synthaseUniRule annotation (EC:5.4.99.-UniRule annotation)
Gene namesi
Ordered Locus Names:SPT_1270Imported
OrganismiStreptococcus pneumoniae (strain Taiwan19F-14)Imported
Taxonomic identifieri487213 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007961 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi487213.SPT_1270.

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase RluA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275919.
KOiK06180.
OMAiPSITHYE.
OrthoDBiEOG6P070X.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CRW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIKIETGGL RLDKALSDLS ELSRSLANEQ IKSGQVLVNG QVKKAKYTVQ
60 70 80 90 100
EGDVVTYHVP EPEVLEYVAE DLPLEIVYQD EDVAVVNKPQ GMVVHPSAGH
110 120 130 140 150
TSGTLVNALM YHIKDLSGIN GVLRPGIVHR IDKDTSGLLM IAKNDDAHLA
160 170 180 190 200
LAQELKDKKS LRKYWAIVHG NLPNDRGVIE APIGRSEKDR KKQAVTAKGK
210 220 230 240 250
PAVTRFHVLE RFGDYSLVEL QLETGRTHQI RVHMAYIGHS VAGDEVYGPR
260 270 280 290
KTLKGHGQFL HAKTLGFTHP RTGKTLEFKA DIPEIFKETL ERLRK
Length:295
Mass (Da):32,841
Last modified:May 26, 2009 - v1
Checksum:i6523294DBCE09964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO23773.1.
RefSeqiYP_002742686.1. NC_012469.1.

Genome annotation databases

EnsemblBacteriaiACO23773; ACO23773; SPT_1270.
KEGGisnt:SPT_1270.
PATRICi19711722. VBIStrPne22502_1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO23773.1.
RefSeqiYP_002742686.1. NC_012469.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi487213.SPT_1270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO23773; ACO23773; SPT_1270.
KEGGisnt:SPT_1270.
PATRICi19711722. VBIStrPne22502_1308.

Phylogenomic databases

eggNOGiCOG0564.
HOGENOMiHOG000275919.
KOiK06180.
OMAiPSITHYE.
OrthoDBiEOG6P070X.

Enzyme and pathway databases

BioCyciSPNE487213:GI07-1235-MONOMER.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR006225. PsdUridine_synth_RluC/D.
IPR006224. PsdUridine_synth_RluC/D_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00005. rluA_subfam. 1 hit.
PROSITEiPS01129. PSI_RLU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain Taiwan19F-14."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Taiwan19F-14Imported.

Entry informationi

Entry nameiC1CRW4_STRZT
AccessioniPrimary (citable) accession number: C1CRW4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 1, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.