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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacA (lacA), Galactose-6-phosphate isomerase subunit LacB (lacB)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPNE487213:GI07-1007-MONOMER.
UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:SPT_1033
OrganismiStreptococcus pneumoniae (strain Taiwan19F-14)
Taxonomic identifieri487213 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Galactose-6-phosphate isomerase subunit LacAPRO_1000185401Add
BLAST

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

C1CRA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVIGADAA GLRLKEVVKD FLEKENFHLV DVTAEGQDFV DVTLAVAAEV
60 70 80 90 100
NKEEQNLGIV IDAYGAGPFI VATKIKGMVA AEVSDERSAY MTRSHNNSRM
110 120 130 140
ITMGAQLVGD ELAKNIAKGF VNGKYDGGRH QIRVDMLNKM G
Length:141
Mass (Da):15,256
Last modified:May 26, 2009 - v1
Checksum:i78C3EC5EBB1445BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO23234.1.
RefSeqiWP_000029270.1. NC_012469.1.

Genome annotation databases

EnsemblBacteriaiACO23234; ACO23234; SPT_1033.
KEGGisnt:SPT_1033.
PATRICi19711237. VBIStrPne22502_1069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO23234.1.
RefSeqiWP_000029270.1. NC_012469.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO23234; ACO23234; SPT_1033.
KEGGisnt:SPT_1033.
PATRICi19711237. VBIStrPne22502_1069.

Phylogenomic databases

HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.
BioCyciSPNE487213:GI07-1007-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain Taiwan19F-14."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Taiwan19F-14.

Entry informationi

Entry nameiLACA_STRZT
AccessioniPrimary (citable) accession number: C1CRA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.