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C1CQI2

- THIM1_STRZT

UniProt

C1CQI2 - THIM1_STRZT

Protein

Hydroxyethylthiazole kinase 1

Gene

thiM1

Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391Substrate; via amide nitrogenUniRule annotation
    Binding sitei115 – 1151ATPUniRule annotation
    Binding sitei160 – 1601ATPUniRule annotation
    Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE487213:GI07-722-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinase 1UniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase 1UniRule annotation
    Short name:
    TH kinase 1UniRule annotation
    Short name:
    Thz kinase 1UniRule annotation
    Gene namesi
    Name:thiM1UniRule annotation
    Ordered Locus Names:SPT_0733
    OrganismiStreptococcus pneumoniae (strain Taiwan19F-14)
    Taxonomic identifieri487213 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000007961: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Hydroxyethylthiazole kinase 1PRO_1000198134Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi487213.SPT_0733.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CQI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiTISESTY.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1CQI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLKLLKEK APLVICITND VVKNFTANGL VALGASPAMS EFPADLEDLL    50
    KYAGGLLINI GTLTDENWKL YQAALKIAEK YNVPAVLDPV ACGAGEYRKK 100
    VADDLINNYK LAAIRGNAGE IASLVGIDVA SKGVDSAGVD NIDEIALAAN 150
    EKFNIPIVVT GEVDAIAVNG EVVTIHNGSA MMPKVIGTGC LLGAVVASFI 200
    GLEKGQELKS LETAMLVYNI AGEIAEKRPN GHLPGTFKAE FINALYEITD 250
    EDVKEFKRVK 260
    Length:260
    Mass (Da):27,561
    Last modified:May 26, 2009 - v1
    Checksum:iCC3C8551E0349428
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000921 Genomic DNA. Translation: ACO22303.1.
    RefSeqiYP_002742204.1. NC_012469.1.

    Genome annotation databases

    EnsemblBacteriaiACO22303; ACO22303; SPT_0733.
    GeneIDi7686535.
    KEGGisnt:SPT_0733.
    PATRICi19710615. VBIStrPne22502_0761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000921 Genomic DNA. Translation: ACO22303.1 .
    RefSeqi YP_002742204.1. NC_012469.1.

    3D structure databases

    ProteinModelPortali C1CQI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 487213.SPT_0733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO22303 ; ACO22303 ; SPT_0733 .
    GeneIDi 7686535.
    KEGGi snt:SPT_0733.
    PATRICi 19710615. VBIStrPne22502_0761.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi TISESTY.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci SPNE487213:GI07-722-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain Taiwan19F-14."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Taiwan19F-14.

    Entry informationi

    Entry nameiTHIM1_STRZT
    AccessioniPrimary (citable) accession number: C1CQI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3