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C1CQE7 (TYSY_STRZT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:thyA
Ordered Locus Names:SPT_0693
OrganismStreptococcus pneumoniae (strain Taiwan19F-14) [Complete proteome] [HAMAP]
Taxonomic identifier487213 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Cellular componentCytoplasm
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Thymidylate synthase HAMAP-Rule MF_00008
PRO_1000197265

Sites

Active site1541 By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CQE7 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 3A1FC537CA648C6A

FASTA27932,554
        10         20         30         40         50         60 
MTKADTIFKE NIERILKEGV FSEQARPKYK DGTVANSKYV TGAFSEYDLS KGEFPITTLR 

        70         80         90        100        110        120 
PIAIKSAIKE VLWIYQDQSN SLEVLNDKYN VHYWNDWEVG DTGTIGERYG AVVKKHDIIN 

       130        140        150        160        170        180 
KLLKQLETNP WNRRNIISLW DYQAFEETDG LLPCAFQTMF DVRRVDGEIY LDATLTQRSN 

       190        200        210        220        230        240 
DMLVAHHINA MQYVALQMMI AKHFGWKVGK FFYFINNLHI YDNQFEQAQE LLRREPSNCQ 

       250        260        270 
PRLVLNVPDG TNFFDIKAED FELVDYDPVK PQLKFDLAI 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain Taiwan19F-14."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Taiwan19F-14.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000921 Genomic DNA. Translation: ACO22621.1.
RefSeqYP_002742169.1. NC_012469.1.

3D structure databases

ProteinModelPortalC1CQE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING487213.SPT_0693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO22621; ACO22621; SPT_0693.
GeneID7686588.
KEGGsnt:SPT_0693.
PATRIC19710529. VBIStrPne22502_0717.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0207.
HOGENOMHOG000257898.
KOK00560.
OMAANPWNRR.
OrthoDBEOG6K6V53.
ProtClustDBPRK01827.

Enzyme and pathway databases

BioCycSPNE487213:GI07-684-MONOMER.
UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_STRZT
AccessionPrimary (citable) accession number: C1CQE7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways