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C1CNT2

- C1CNT2_STRZT

UniProt

C1CNT2 - C1CNT2_STRZT

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Protein

N5-carboxyaminoimidazole ribonucleotide synthase

Gene

purK

Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).UniRule annotation

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 5-(carboxyamino)imidazole ribonucleotide synthase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: InterPro
  4. phosphoribosylaminoimidazole carboxylase activity Source: InterPro

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation, LyaseImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE487213:GI07-92-MONOMER.
UniPathwayiUPA00074; UER00942.

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide synthaseUniRule annotation (EC:6.3.4.18UniRule annotation)
Short name:
N5-CAIR synthaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetaseUniRule annotation
Gene namesi
Name:purKImported
Ordered Locus Names:SPT_0092Imported
OrganismiStreptococcus pneumoniae (strain Taiwan19F-14)Imported
Taxonomic identifieri487213 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000007961: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi487213.SPT_0092.

Structurei

3D structure databases

ProteinModelPortaliC1CNT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PurK/PurT family.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034029.
KOiK01589.
OMAiNQILHES.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CNT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSKTIGII GGGQLGQMMA TSAIYMGHKV IALDPAADCP ASRVAEIIVA
60 70 80 90 100
PYNDVDALRQ LADRCDVLTY EFENVDADGL DAVIKDGQLP QGTDLLRISQ
110 120 130 140 150
NRIFEKDFLS NKAQVTVAPY KVVTSSLDLA DIDLSKNYVL KTATGGYDGH
160 170 180 190 200
GQKVIRSEAD LEAAYALADS ADCVLEEFVN FDLEISVIVS GNGKEVTFFP
210 220 230 240 250
VQENIHRNNI LSKTIVPARI SESLADKAKA MAVRIAEQLN LSGTLCVEMF
260 270 280 290 300
ATDDDVIVNE IAPRPHNSGH YSIEACDFSQ FDTHILGVLG APLPVIKLHA
310 320 330 340 350
PAVMLNVLGQ HVEAAEQYVT ENSSAHLHMY GKIEAKHNRK MGHVTLFSDV
360
PDSVDELGEG IDF
Length:363
Mass (Da):39,301
Last modified:May 26, 2009 - v1
Checksum:i410C68BA19CF7FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO22852.1.
RefSeqiYP_002741604.1. NC_012469.1.

Genome annotation databases

EnsemblBacteriaiACO22852; ACO22852; SPT_0092.
GeneIDi7686297.
KEGGisnt:SPT_0092.
PATRICi19709284. VBIStrPne22502_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000921 Genomic DNA. Translation: ACO22852.1 .
RefSeqi YP_002741604.1. NC_012469.1.

3D structure databases

ProteinModelPortali C1CNT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 487213.SPT_0092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO22852 ; ACO22852 ; SPT_0092 .
GeneIDi 7686297.
KEGGi snt:SPT_0092.
PATRICi 19709284. VBIStrPne22502_0086.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034029.
KOi K01589.
OMAi NQILHES.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00942 .
BioCyci SPNE487213:GI07-92-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain Taiwan19F-14."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Taiwan19F-14Imported.

Entry informationi

Entry nameiC1CNT2_STRZT
AccessioniPrimary (citable) accession number: C1CNT2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3