Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional ligase/repressor BirA

Gene

birA

Organism
Streptococcus pneumoniae (strain P1031)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.UniRule annotation

Catalytic activityi

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091BiotinUniRule annotation
Binding sitei179 – 1791BiotinUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 3920H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. biotin-[acetyl-CoA-carboxylase] ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular protein modification process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, BiotinUniRule annotation, DNA-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE488223:GHE7-1867-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ligase/repressor BirAUniRule annotation
Alternative name(s):
Biotin--[acetyl-CoA-carboxylase] ligaseUniRule annotation
Biotin--protein ligaseUniRule annotation
Biotin-[acetyl-CoA carboxylase] synthetaseUniRule annotation
Gene namesi
Name:birAUniRule annotation
Ordered Locus Names:SPP_1906Imported
OrganismiStreptococcus pneumoniae (strain P1031)Imported
Taxonomic identifieri488223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002202 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi488223.SPP_1906.

Structurei

3D structure databases

ProteinModelPortaliC1CML2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 251190BPL/LPL catalyticUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1153Biotin bindingUniRule annotation

Sequence similaritiesi

Belongs to the biotin--protein ligase family.UniRule annotation
Contains 1 BPL/LPL catalytic domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0340.
HOGENOMiHOG000041811.
KOiK03524.
OMAiIYSADIE.
OrthoDBiEOG6DNTBX.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00978. Bifunct_BirA.
InterProiIPR030855. Bifunct_BirA.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LipA_LipB.
IPR013196. HTH_11.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.

Sequencei

Sequence statusi: Complete.

C1CML2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYQAVYQI LSKETDYISG EKIAEKLSLS RTAIWKAIKR LEQEGIEIDS
60 70 80 90 100
IKNRGYKLMN GDLILPEILE ENLPIKVSFK PETKSTQLDA KEAIDLGHEA
110 120 130 140 150
NTLYLASYQT AGRGRFQRSF YSPQGGIYMT LHLKPNLPYD KLPSYTLLVA
160 170 180 190 200
GAVYKAIKNL TLIDVDIKWV NDIYLNNHKI GGILTEAMTS VETGLVTDII
210 220 230 240 250
IGVGINFTIK DFPQELKEKA ASLFKATAPI TRNELIIEIW RAFFETPAEE
260 270 280 290 300
LLYLYKKQSF ILGKEVTFTL EQKDYKGLAK DISENGKLLV QCDNGKEIWL
310
NSGEISLNSW K
Length:311
Mass (Da):35,228
Last modified:May 26, 2009 - v1
Checksum:i36547B949CD1A8D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000920 Genomic DNA. Translation: ACO22201.1.
RefSeqiYP_002739000.1. NC_012467.1.

Genome annotation databases

EnsemblBacteriaiACO22201; ACO22201; SPP_1906.
KEGGispp:SPP_1906.
PATRICi32461186. VBIStrPne91701_1987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000920 Genomic DNA. Translation: ACO22201.1.
RefSeqiYP_002739000.1. NC_012467.1.

3D structure databases

ProteinModelPortaliC1CML2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi488223.SPP_1906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO22201; ACO22201; SPP_1906.
KEGGispp:SPP_1906.
PATRICi32461186. VBIStrPne91701_1987.

Phylogenomic databases

eggNOGiCOG0340.
HOGENOMiHOG000041811.
KOiK03524.
OMAiIYSADIE.
OrthoDBiEOG6DNTBX.

Enzyme and pathway databases

BioCyciSPNE488223:GHE7-1867-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00978. Bifunct_BirA.
InterProiIPR030855. Bifunct_BirA.
IPR004408. Biotin_CoA_COase_ligase.
IPR003142. BPL_C.
IPR004143. BPL_LipA_LipB.
IPR013196. HTH_11.
IPR008988. Transcriptional_repressor_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR12835. PTHR12835. 1 hit.
PfamiPF02237. BPL_C. 1 hit.
PF03099. BPL_LplA_LipB. 1 hit.
PF08279. HTH_11. 1 hit.
[Graphical view]
SUPFAMiSSF50037. SSF50037. 1 hit.
TIGRFAMsiTIGR00121. birA_ligase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain P1031."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P1031Imported.

Entry informationi

Entry nameiC1CML2_STRZP
AccessioniPrimary (citable) accession number: C1CML2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: April 29, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.