C1CMI5 (SCPB_STRZP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Segregation and condensation protein B

Gene names

Name:	scpB
Ordered Locus Names:	SPP_1875

Organism

Streptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]

Taxonomic identifier

488223 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves By similarity. HAMAP-Rule MF_01804
Subunit structure	Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA By similarity.
Subcellular location	Cytoplasm By similarity. Note: Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells By similarity.
Sequence similarities	Belongs to the ScpB family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Chromosome partition
Cellular component	Cytoplasm
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: HAMAP cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome separation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 189

189

Segregation and condensation protein B HAMAP-Rule MF_01804

PRO_1000187546

Secondary structure

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189

Helix Strand Turn

Details...

Helix

3 – 13

11

Turn

14 – 17

4

Helix

21 – 28

8

Helix

32 – 48

17

Beta strand

54 – 59

6

Beta strand

62 – 67

6

Helix

69 – 71

3

Helix

72 – 78

7

Helix

83 – 85

3

Helix

89 – 101

13

Beta strand

103 – 105

3

Helix

106 – 113

8

Helix

118 – 126

9

Beta strand

129 – 135

7

Beta strand

143 – 147

5

Helix

149 – 155

7

Helix

160 – 162

3

Sequences

	Sequence		Length	Mass (Da)
	C1CMI5 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: B69B8B46CAED599A	FASTA	189	21,038
	10 20 30 40 50 60 MSTLAKIEAL LFVAGEDGIR VRQLAELLSL PPTGIQQSLG KLAQKYEKDP DSSLALIETS 70 80 90 100 110 120 GAYRLVTKPQ FAEILKEYSK APINQSLSRA ALETLSIIAY KQPITRIEID AIRGVNSSGA 130 140 150 160 170 180 LAKLQAFDLI KEDGKKEVLG RPNLYVTTDY FLDYMGINHL EELPVIDELE IQAQESQLFG ERIEEDENQ

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain P1031." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P1031.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

CP000920 Genomic DNA. Translation: ACO20208.1.

RefSeq

YP_002738973.1. NC_012467.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4I98	X-ray	2.80	B/C	1-183	[»]

ProteinModelPortal

C1CMI5.

ModBase

Search...

Protein-protein interaction databases

STRING

488223.SPP_1875.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

ACO20208; ACO20208; SPP_1875.

GeneID

7681497.

KEGG

spp:SPP_1875.

PATRIC

32461124. VBIStrPne91701_1956.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG1386.

HOGENOM

HOG000242838.

KO

K06024.

OMA

HTYKLTT.

ProtClustDB

PRK00135.

Family and domain databases

Gene3D

1.10.10.10. 2 hits.

HAMAP

MF_01804. ScpB.

InterPro

IPR005234. ScpB_csome_segregation_prot.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]

Pfam

PF04079. DUF387. 1 hit.
[Graphical view]

PIRSF

PIRSF019345. ScpB. 1 hit.

TIGRFAMs

TIGR00281. TIGR00281. 1 hit.

ProtoNet

Search...

Entry information

Entry name

SCPB_STRZP

Accession

Primary (citable) accession number: C1CMI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program