C1CMD5 (TRPC_STRZP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SPP_1822

Organism

Streptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]

Taxonomic identifier

488223 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000198790

Sequences

	Sequence		Length	Mass (Da)
	C1CMD5 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 8A13FBEE27A2D85C	FASTA	255	28,940
	10 20 30 40 50 60 MSQEFLARIL EQKAREVEQM KLEQIQPLRQ TYRLAEFLKN HQDRLQVIAE VKKASPSLGD 70 80 90 100 110 120 INLDVDIVQQ AQTYEENGAV MISVLTDEVF FKGHLDYLRE ISSQVEIPTL NKDFIIDEKQ 130 140 150 160 170 180 IIRARNAGAT VILLIVAALS EERLKELYDY ATELGLEVLV ETHNLAELEV AHRLGAEIIG 190 200 210 220 230 240 VNNRNLTTFE VDLQTSVDLA PYFEEGRYYI SESAIFTGQD AERLAPYFNG ILVGTALMQA 250 ENVAQRIKEL QIDKG

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain P1031." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P1031.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000920 Genomic DNA. Translation: ACO21684.1.
RefSeq	YP_002738923.1. NC_012467.1.
3D structure databases
ProteinModelPortal	C1CMD5.
ModBase	Search...
Protein-protein interaction databases
STRING	C1CMD5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000081632; EBSTRP00000075963; EBSTRG00000080221.
GeneID	7681262.
GenomeReviews	Gene locus SPP_1822 in contig CP000920_GR.
KEGG	spp:SPP_1822.
PATRIC	32461004. VBIStrPne91701_1896.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000029214.
OMA	FETDINT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	SPNE1313-1:SPP_1822-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRZP

Accession

Primary (citable) accession number: C1CMD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program