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C1CLX1

- SYT_STRZP

UniProt

C1CLX1 - SYT_STRZP

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Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Streptococcus pneumoniae (strain P1031)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi336 – 3361Zinc; catalyticUniRule annotation
Metal bindingi387 – 3871Zinc; catalyticUniRule annotation
Metal bindingi517 – 5171Zinc; catalyticUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSPNE488223:GHE7-1617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
Alternative name(s):
Threonyl-tRNA synthetaseUniRule annotation
Short name:
ThrRSUniRule annotation
Gene namesi
Name:thrSUniRule annotation
Ordered Locus Names:SPP_1650
OrganismiStreptococcus pneumoniae (strain P1031)
Taxonomic identifieri488223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002202: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Threonine--tRNA ligasePRO_1000199572Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi488223.SPP_1650.

Structurei

3D structure databases

ProteinModelPortaliC1CLX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni242 – 540299CatalyticAdd
BLAST

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0441.
HOGENOMiHOG000003879.
KOiK01868.
OMAiADGYQHV.
OrthoDBiEOG61KBFJ.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_00184. Thr_tRNA_synth.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamiPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSiPR01047. TRNASYNTHTHR.
SMARTiSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00418. thrS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CLX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINITFPDGA VREFESGVTT FEIAQSISNS LAKKALAGKF NGKLIDTTRA
60 70 80 90 100
ITEDGSIEIV TPDHEDALPI LRHSAAHLFA QAARRLFPDI HLGVGPAIED
110 120 130 140 150
GFYYDTDNTA GQISNEDLPR IEEEMQKIVK ENFPSIREEV TKDEAREIFK
160 170 180 190 200
NDPYKLELIE EHSEDEGGLT IYRQGEYVDL CRGPHVPSTG RIQIFHLLHV
210 220 230 240 250
AGAYWRGNSD NAMMQRIYGT AWFDKKDLKN YLQMREEAKE RDHRKLGKEL
260 270 280 290 300
DLFIISQEVG QGLPFWLPNG ATIRRELERY IVNKELASGY QHVYTPPLAS
310 320 330 340 350
VELYKTSGHW DHYQEDMFPT MDMGDGEEFV LRPMNCPHHI QVFKHHVHSY
360 370 380 390 400
RELPIRIAEI GMMHRYEKSG ALTGLQRVRE MSLNDGHLFV TPEQIQEEFQ
410 420 430 440 450
RALQLIIDVY EDFNLTDYRF RLSLRDPQDT HKYFDNDEMW ENAQTMLRAA
460 470 480 490 500
LDEMGVNYFE AEGEAAFYGP KLDIQIKTAL GKEETLSTIQ LDFLLPERFD
510 520 530 540 550
LKYIGADGED HRPVMIHRGV ISTMERFTAI LIENYKGAFP TWLAPHQVTL
560 570 580 590 600
IPVSNEKHVD YAWEVAKKLR DRGVRADVDE RNEKMQFKIR ASQTSKIPYQ
610 620 630 640
LIVGDKEMED ETVNVRRYGQ KETQTVSVDN FVQAILADIA NKSRVEK
Length:647
Mass (Da):74,664
Last modified:May 26, 2009 - v1
Checksum:i311E63158C457877
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000920 Genomic DNA. Translation: ACO21023.1.
RefSeqiYP_002738759.1. NC_012467.1.

Genome annotation databases

EnsemblBacteriaiACO21023; ACO21023; SPP_1650.
GeneIDi7681679.
KEGGispp:SPP_1650.
PATRICi32460631. VBIStrPne91701_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000920 Genomic DNA. Translation: ACO21023.1 .
RefSeqi YP_002738759.1. NC_012467.1.

3D structure databases

ProteinModelPortali C1CLX1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 488223.SPP_1650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO21023 ; ACO21023 ; SPP_1650 .
GeneIDi 7681679.
KEGGi spp:SPP_1650.
PATRICi 32460631. VBIStrPne91701_1711.

Phylogenomic databases

eggNOGi COG0441.
HOGENOMi HOG000003879.
KOi K01868.
OMAi ADGYQHV.
OrthoDBi EOG61KBFJ.

Enzyme and pathway databases

BioCyci SPNE488223:GHE7-1617-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_00184. Thr_tRNA_synth.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view ]
Pfami PF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view ]
PRINTSi PR01047. TRNASYNTHTHR.
SMARTi SM00863. tRNA_SAD. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00418. thrS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain P1031."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P1031.

Entry informationi

Entry nameiSYT_STRZP
AccessioniPrimary (citable) accession number: C1CLX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3