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C1CLX1 (SYT_STRZP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Threonine--tRNA ligase

EC=6.1.1.3
Alternative name(s):
Threonyl-tRNA synthetase
Short name=ThrRS
Gene names
Name:thrS
Ordered Locus Names:SPP_1650
OrganismStreptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]
Taxonomic identifier488223 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP-Rule MF_00184

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00184

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00184

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00184.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

threonine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 647647Threonine--tRNA ligase HAMAP-Rule MF_00184
PRO_1000199572

Regions

Region242 – 540299Catalytic HAMAP-Rule MF_00184

Sites

Metal binding3361Zinc; catalytic By similarity
Metal binding3871Zinc; catalytic By similarity
Metal binding5171Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CLX1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 311E63158C457877

FASTA64774,664
        10         20         30         40         50         60 
MINITFPDGA VREFESGVTT FEIAQSISNS LAKKALAGKF NGKLIDTTRA ITEDGSIEIV 

        70         80         90        100        110        120 
TPDHEDALPI LRHSAAHLFA QAARRLFPDI HLGVGPAIED GFYYDTDNTA GQISNEDLPR 

       130        140        150        160        170        180 
IEEEMQKIVK ENFPSIREEV TKDEAREIFK NDPYKLELIE EHSEDEGGLT IYRQGEYVDL 

       190        200        210        220        230        240 
CRGPHVPSTG RIQIFHLLHV AGAYWRGNSD NAMMQRIYGT AWFDKKDLKN YLQMREEAKE 

       250        260        270        280        290        300 
RDHRKLGKEL DLFIISQEVG QGLPFWLPNG ATIRRELERY IVNKELASGY QHVYTPPLAS 

       310        320        330        340        350        360 
VELYKTSGHW DHYQEDMFPT MDMGDGEEFV LRPMNCPHHI QVFKHHVHSY RELPIRIAEI 

       370        380        390        400        410        420 
GMMHRYEKSG ALTGLQRVRE MSLNDGHLFV TPEQIQEEFQ RALQLIIDVY EDFNLTDYRF 

       430        440        450        460        470        480 
RLSLRDPQDT HKYFDNDEMW ENAQTMLRAA LDEMGVNYFE AEGEAAFYGP KLDIQIKTAL 

       490        500        510        520        530        540 
GKEETLSTIQ LDFLLPERFD LKYIGADGED HRPVMIHRGV ISTMERFTAI LIENYKGAFP 

       550        560        570        580        590        600 
TWLAPHQVTL IPVSNEKHVD YAWEVAKKLR DRGVRADVDE RNEKMQFKIR ASQTSKIPYQ 

       610        620        630        640 
LIVGDKEMED ETVNVRRYGQ KETQTVSVDN FVQAILADIA NKSRVEK 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain P1031."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P1031.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000920 Genomic DNA. Translation: ACO21023.1.
RefSeqYP_002738759.1. NC_012467.1.

3D structure databases

ProteinModelPortalC1CLX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING488223.SPP_1650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO21023; ACO21023; SPP_1650.
GeneID7681679.
KEGGspp:SPP_1650.
PATRIC32460631. VBIStrPne91701_1711.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0441.
HOGENOMHOG000003879.
KOK01868.
OMAADGYQHV.
OrthoDBEOG61KBFJ.

Enzyme and pathway databases

BioCycSPNE488223:GHE7-1617-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPMF_00184. Thr_tRNA_synth.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. SSF52954. 1 hit.
SSF55186. SSF55186. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsTIGR00418. thrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYT_STRZP
AccessionPrimary (citable) accession number: C1CLX1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries