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C1CLX1

- SYT_STRZP

UniProt

C1CLX1 - SYT_STRZP

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Streptococcus pneumoniae (strain P1031)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi336 – 3361Zinc; catalyticUniRule annotation
    Metal bindingi387 – 3871Zinc; catalyticUniRule annotation
    Metal bindingi517 – 5171Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSPNE488223:GHE7-1617-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:SPP_1650
    OrganismiStreptococcus pneumoniae (strain P1031)
    Taxonomic identifieri488223 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002202: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 647647Threonine--tRNA ligasePRO_1000199572Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi488223.SPP_1650.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CLX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni242 – 540299CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003879.
    KOiK01868.
    OMAiADGYQHV.
    OrthoDBiEOG61KBFJ.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CLX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINITFPDGA VREFESGVTT FEIAQSISNS LAKKALAGKF NGKLIDTTRA    50
    ITEDGSIEIV TPDHEDALPI LRHSAAHLFA QAARRLFPDI HLGVGPAIED 100
    GFYYDTDNTA GQISNEDLPR IEEEMQKIVK ENFPSIREEV TKDEAREIFK 150
    NDPYKLELIE EHSEDEGGLT IYRQGEYVDL CRGPHVPSTG RIQIFHLLHV 200
    AGAYWRGNSD NAMMQRIYGT AWFDKKDLKN YLQMREEAKE RDHRKLGKEL 250
    DLFIISQEVG QGLPFWLPNG ATIRRELERY IVNKELASGY QHVYTPPLAS 300
    VELYKTSGHW DHYQEDMFPT MDMGDGEEFV LRPMNCPHHI QVFKHHVHSY 350
    RELPIRIAEI GMMHRYEKSG ALTGLQRVRE MSLNDGHLFV TPEQIQEEFQ 400
    RALQLIIDVY EDFNLTDYRF RLSLRDPQDT HKYFDNDEMW ENAQTMLRAA 450
    LDEMGVNYFE AEGEAAFYGP KLDIQIKTAL GKEETLSTIQ LDFLLPERFD 500
    LKYIGADGED HRPVMIHRGV ISTMERFTAI LIENYKGAFP TWLAPHQVTL 550
    IPVSNEKHVD YAWEVAKKLR DRGVRADVDE RNEKMQFKIR ASQTSKIPYQ 600
    LIVGDKEMED ETVNVRRYGQ KETQTVSVDN FVQAILADIA NKSRVEK 647
    Length:647
    Mass (Da):74,664
    Last modified:May 26, 2009 - v1
    Checksum:i311E63158C457877
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000920 Genomic DNA. Translation: ACO21023.1.
    RefSeqiYP_002738759.1. NC_012467.1.

    Genome annotation databases

    EnsemblBacteriaiACO21023; ACO21023; SPP_1650.
    GeneIDi7681679.
    KEGGispp:SPP_1650.
    PATRICi32460631. VBIStrPne91701_1711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000920 Genomic DNA. Translation: ACO21023.1 .
    RefSeqi YP_002738759.1. NC_012467.1.

    3D structure databases

    ProteinModelPortali C1CLX1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 488223.SPP_1650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO21023 ; ACO21023 ; SPP_1650 .
    GeneIDi 7681679.
    KEGGi spp:SPP_1650.
    PATRICi 32460631. VBIStrPne91701_1711.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003879.
    KOi K01868.
    OMAi ADGYQHV.
    OrthoDBi EOG61KBFJ.

    Enzyme and pathway databases

    BioCyci SPNE488223:GHE7-1617-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain P1031."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P1031.

    Entry informationi

    Entry nameiSYT_STRZP
    AccessioniPrimary (citable) accession number: C1CLX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3