C1CLN3 (PPAC_STRZP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable manganese-dependent inorganic pyrophosphatase
EC=3.6.1.1

Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name=PPase

Gene names

Name:	ppaC
Ordered Locus Names:	SPP_1557

Organism

Streptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]

Taxonomic identifier

488223 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP-Rule MF_00207
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PPase class C family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Probable manganese-dependent inorganic pyrophosphatase HAMAP-Rule MF_00207		PRO_1000124663
Sites
	Metal binding	9	1	Manganese 1 By similarity
	Metal binding	13	1	Manganese 1 By similarity
	Metal binding	15	1	Manganese 2 By similarity
	Metal binding	77	1	Manganese 1 By similarity
	Metal binding	77	1	Manganese 2 By similarity
	Metal binding	99	1	Manganese 2 By similarity
	Metal binding	151	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1CLN3 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 08FCC9B1207657EB	FASTA	311	33,479
	10 20 30 40 50 60 MSKILVFGHQ NPDSDAIGSS VAFAYLAKEA YGLDTEAVAL GTPNEETAFV LNYFGVEAPR 70 80 90 100 110 120 VITSAKAEGA EQVILTDHNE FQQSVSDIAE VEVYGVVDHH RVANFETASP LYMRLEPVGS 130 140 150 160 170 180 ASSIVYRMFK EHGVAVPKEI AGLMLSGLIS DTLLLKSPTT HPTDKIIAPE LAELAGVNLE 190 200 210 220 230 240 EYGLAMLKAG TNLASKSAEE LIDIDAKTFE LNGNNVRVAQ VNTVDIAEVL ERQAEIEAAM 250 260 270 280 290 300 QAANESNGYS DFVLMITDIV NSNSEILALG ANMDKVEAAF NFKLENNHAF LAGAVSRKKQ 310 VVPQLTESFN A

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain P1031." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P1031.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000920 Genomic DNA. Translation: ACO21671.1.
RefSeq	YP_002738671.1. NC_012467.1.
3D structure databases
ProteinModelPortal	C1CLN3.
SMR	C1CLN3. Positions 2-311.
ModBase	Search...
Protein-protein interaction databases
STRING	488223.SPP_1557.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO21671; ACO21671; SPP_1557.
GeneID	7681850.
KEGG	spp:SPP_1557.
PATRIC	32460431. VBIStrPne91701_1610.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1227.
HOGENOM	HOG000223999.
KO	K15986.
OMA	KFGFEAP.
ProtClustDB	PRK05427.
Family and domain databases
HAMAP	MF_00207. PPase_C.
InterPro	IPR004097. DHHA2. IPR022934. Mn-dep_inorganic_PyrPase. IPR001667. Pesterase_RecJ. [Graphical view]
Pfam	PF01368. DHH. 1 hit. PF02833. DHHA2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPAC_STRZP

Accession

Primary (citable) accession number: C1CLN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program