C1CL86 (AROD_STRZP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SPP_1397

Organism

Streptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]

Taxonomic identifier

488223 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000124790
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	143	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1CL86 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 9B9F54DA730EBC5A	FASTA	225	25,763
	10 20 30 40 50 60 MKLIVSVMPR SLEEAQALDD TRYLDADIIE WRADYLPKEA ILQVAPAIFE KFAGRELVFT 70 80 90 100 110 120 LRTRSEGGEI DLSPEEYIHL IKEVAQLYQP DYIDFEYYSY KDVFEEMLDF PNLVLSYHNF 130 140 150 160 170 180 QETPENMMEI LSELTILNPK LVKVAVMAHT EQDVLDLMNY TRGFKTLNPE QEYVTISMGK 190 200 210 220 VGKVSRITAD VTGSSWSFAS LDEVSAPGQI SLASMKKIRE ILDEA

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain P1031." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P1031.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000920 Genomic DNA. Translation: ACO21246.1.
RefSeq	YP_002738524.1. NC_012467.1.
3D structure databases
ProteinModelPortal	C1CL86.
ModBase	Search...
Protein-protein interaction databases
STRING	C1CL86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000080873; EBSTRP00000075955; EBSTRG00000081265.
GeneID	7681873.
GenomeReviews	Gene locus SPP_1397 in contig CP000920_GR.
KEGG	spp:SPP_1397.
PATRIC	32460107. VBIStrPne91701_1448.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027890.
OMA	VARRTVI.
ProtClustDB	PRK02412.
Enzyme and pathway databases
BioCyc	SPNE1313-1:SPP_1397-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STRZP

Accession

Primary (citable) accession number: C1CL86

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program