C1CKT2 (C1CKT2_STRZP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phospho-beta-galactosidase 2 HAMAP MF_01574
EC=3.2.1.85 HAMAP MF_01574

Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 2 HAMAP MF_01574
P-beta-Gal 2 HAMAP MF_01574

Gene names

Name:	lacG2 HAMAP MF_01574 EMBL ACO21988.1
Ordered Locus Names:	SPP_1227

Organism

Streptococcus pneumoniae (strain P1031) [Complete proteome] [HAMAP]

Taxonomic identifier

488223 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. RuleBase RU004469 HAMAP MF_01574
Pathway	Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. RuleBase RU004469 HAMAP MF_01574
Sequence similarities	Belongs to the glycosyl hydrolase 1 family. HAMAP MF_01574 RuleBase RU003690

Ontologies

Keywords
Molecular function	Glycosidase HAMAP MF_01574 RuleBase RU004468 EMBL ACO21988.1 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	6-phospho-beta-galactosidase activity Inferred from electronic annotation. Source: HAMAP cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	160	1	Proton donor By similarity HAMAP MF_01574
	Active site	375	1	Nucleophile By similarity HAMAP MF_01574

Sequences

	Sequence		Length	Mass (Da)
	C1CKT2 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 647572DA6955BACD	FASTA	468	53,927
	10 20 30 40 50 60 MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS DFYNRYPVDL 70 80 90 100 110 120 KLAEEYGVNG IRISIAWSRI FPTGYGQVNV KGVEFYHNLF AECHKRHVEP FVTLHHFDTP 130 140 150 160 170 180 EALHSNGDFL NRENIEHFVD YAAFCFEEFP EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY 190 200 210 220 230 240 DLAKVFQSHH NMMVSHARAV KLYKDKGYKG EIGVVHALPT KYPLDPKNPA DVRAAELEDI 250 260 270 280 290 300 IHNKFILDAT YLGRYSAETM EGVNHILSVN GGSLDLREED FTTLEAAKDL NDFLGINYYM 310 320 330 340 350 360 SDWMEAFDGE TEIIHNGKGE KGSSKYQIKG VGRRVAPDYV PRTDWDWIIY PQGLYDQIIR 370 380 390 400 410 420 VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ HLEILSDAIA DGANVKGYFI 430 440 450 460 WSLMDVFSWS NGYEKRYGLF YVDFETQERY PKKSAHWYKK VAETQIID

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain P1031." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000920 Genomic DNA. Translation: ACO21988.1.
RefSeq	YP_002738370.1. NC_012467.1.
3D structure databases
ProteinModelPortal	C1CKT2.
ModBase	Search...
Protein-protein interaction databases
STRING	C1CKT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000080567; EBSTRP00000074748; EBSTRG00000080780.
GeneID	7680997.
GenomeReviews	Gene locus SPP_1227 in contig CP000920_GR.
KEGG	spp:SPP_1227.
PATRIC	32459749. VBIStrPne91701_1271.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027409.
OMA	FVNYAEF.
ProtClustDB	PRK13511.
Enzyme and pathway databases
BioCyc	SPNE1313-1:SPP_1227-MONOMER.
Family and domain databases
HAMAP	MF_01574. LacG. [Tree]
InterPro	IPR005928. 6P-beta-galactosidase. IPR001360. Glyco_hydro_1. IPR018120. Glyco_hydro_1_AS. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K01220.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMs	TIGR01233. LacG. 1 hit.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C1CKT2_STRZP

Accession

Primary (citable) accession number: C1CKT2

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)