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C1CID7

- SYL_STRZP

UniProt

C1CID7 - SYL_STRZP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus pneumoniae (strain P1031)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei613 – 6131ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE488223:GHE7-298-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:SPP_0306
    OrganismiStreptococcus pneumoniae (strain P1031)
    Taxonomic identifieri488223 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002202: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833Leucine--tRNA ligasePRO_1000199228Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi488223.SPP_0306.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5212"HIGH" regionAdd
    BLAST
    Motifi610 – 6145"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiNENGVEG.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CID7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFYNHKEIE PKWQGYWAEH HTFKTGTDAS KPKFYALDMF PYPSGAGLHV    50
    GHPEGYTATD ILSRYKRAQG YNVLHPMGWD AFGLPAEQYA MDTGNDPAEF 100
    TAENIANFKR QINALGFSYD WDREVNTTDP NYYKWTQWIF TKLYEKGLAY 150
    EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA 200
    ERLLNDLDEL DWSESIKDMQ RNWIGKSTGA NVTFKVKGTD KEFTVFTTRP 250
    DTLFGATFTV LAPEHELVDA ITSTEQAEAV ADYKHQASLK SDLARTDLAK 300
    EKTGVWTGAY AINPVNGKEI PIWIADYVLA SYGTGAVMAV PAHDQRDWEF 350
    AKQFDLPIVE VLEGGNVEEA AYTEDGLHVN SDFLDGLNKE DAIAKIVACL 400
    EEKGCGQEKV TYRLRDWLFS RQRYWGEPIP IIHWEDGTST AVPESELPLV 450
    LPVTKDIRPS GTGESPLANL TDWLEVTRED GVKGRRETNT MPQWAGSSWY 500
    YLRYIDPHNT EKLADEDLLK QWLPVDIYVG GAEHAVLHLL YARFWHKFLY 550
    DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK RDGSFFHVET 600
    GEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS 650
    EEGLEGSRKF LDRVYRLITS KEIIAENNGA LDKVYNETVK AVTEQIESLK 700
    FNTAIAQLMV FVNAANKEDK LYVDYAKGFI QLIAPFAPHL AEELWQTVAA 750
    TGESISYVAW PTWDESKLVE DEIEIVVQIK GKVRAKLMVA KDLSREELQE 800
    IALADEKVKV EIDGKEIVKV ISVPNKLVNI VVK 833
    Length:833
    Mass (Da):94,276
    Last modified:May 26, 2009 - v1
    Checksum:i7C049714A29051D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000920 Genomic DNA. Translation: ACO22017.1.
    RefSeqiYP_002737525.1. NC_012467.1.

    Genome annotation databases

    EnsemblBacteriaiACO22017; ACO22017; SPP_0306.
    GeneIDi7682047.
    KEGGispp:SPP_0306.
    PATRICi32457827. VBIStrPne91701_0316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000920 Genomic DNA. Translation: ACO22017.1 .
    RefSeqi YP_002737525.1. NC_012467.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 488223.SPP_0306.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO22017 ; ACO22017 ; SPP_0306 .
    GeneIDi 7682047.
    KEGGi spp:SPP_0306.
    PATRICi 32457827. VBIStrPne91701_0316.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi NENGVEG.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SPNE488223:GHE7-298-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain P1031."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P1031.

    Entry informationi

    Entry nameiSYL_STRZP
    AccessioniPrimary (citable) accession number: C1CID7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3