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C1CHW2

- PUR9_STRZP

UniProt

C1CHW2 - PUR9_STRZP

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Streptococcus pneumoniae (strain P1031)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSPNE488223:GHE7-114-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:SPP_0115
OrganismiStreptococcus pneumoniae (strain P1031)
Taxonomic identifieri488223 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002202: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional purine biosynthesis protein PurHPRO_1000122977Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi488223.SPP_0115.

Structurei

3D structure databases

ProteinModelPortaliC1CHW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

C1CHW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKRVLISVS DKAGIVEFAQ ELKKLGWEII STGGTKVALD NAGVDTIAID
60 70 80 90 100
DVTGFPEMMD GRVKTLHPNI HGGLLARRDL DSHLEAAKDN KIELIDLVVV
110 120 130 140 150
NLYPFKETIL KPDVTYADAV ENIDIGGPSM LRSAAKNHAS VTVVVDPADY
160 170 180 190 200
AVVLDELAAN GETSYETRQR LAAKVFRHTA AYDALIAKYF TAQVGESKPE
210 220 230 240 250
KLTLTYDLKQ PMRYGENPQQ DADFYQKALP TDYSIASAKQ LNGKELSFNN
260 270 280 290 300
IRDADAAIRI IRDFKDSPTV VALKHMNPCG IGQADDIETA WEYAYESDPV
310 320 330 340 350
SIFGGIVVLN REVDAATAEK MHGVFLEIII APSYTDEALA ILINKKKNLR
360 370 380 390 400
ILALPFNAQE ASEVEAEYTG VVGGLLVQNQ DVVKESPADW QVVTKRQPTE
410 420 430 440 450
TEATALEFAW KAIKYVKSNG IIVTNDHMTL GVGPGQTNRV ASVRLAIDQA
460 470 480 490 500
KDRLDGAVLA SDAFFPFADN VEEIAKAGIK AIIQPGGSVR DQESIEAADK
510
YGLTMVFTGV RHFRH
Length:515
Mass (Da):56,307
Last modified:May 26, 2009 - v1
Checksum:iB18098926D049BF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000920 Genomic DNA. Translation: ACO20149.1.
RefSeqiYP_002737350.1. NC_012467.1.

Genome annotation databases

EnsemblBacteriaiACO20149; ACO20149; SPP_0115.
GeneIDi7681646.
KEGGispp:SPP_0115.
PATRICi32457423. VBIStrPne91701_0113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000920 Genomic DNA. Translation: ACO20149.1 .
RefSeqi YP_002737350.1. NC_012467.1.

3D structure databases

ProteinModelPortali C1CHW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 488223.SPP_0115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO20149 ; ACO20149 ; SPP_0115 .
GeneIDi 7681646.
KEGGi spp:SPP_0115.
PATRICi 32457423. VBIStrPne91701_0113.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SPNE488223:GHE7-114-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain P1031."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P1031.

Entry informationi

Entry nameiPUR9_STRZP
AccessioniPrimary (citable) accession number: C1CHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3