C1CHD4 (PLSX_STRZJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphate acyltransferase
EC=2.3.1.n2

Alternative name(s):
Acyl-ACP phosphotransacylase
Acyl-[acyl-carrier-protein]--phosphate acyltransferase
Phosphate-acyl-ACP acyltransferase

Gene names

Name:	plsX
Ordered Locus Names:	SPJ_0061

Organism

Streptococcus pneumoniae (strain JJA) [Complete proteome] [HAMAP]

Taxonomic identifier

488222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible formation of acyl-phosphate (acyl-PO4) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA By similarity. HAMAP-Rule MF_00019
Catalytic activity	Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein]. HAMAP-Rule MF_00019
Pathway	Lipid metabolism; phospholipid metabolism. HAMAP-Rule MF_00019
Subunit structure	Homodimer. Probably interacts with PlsY By similarity.
Subcellular location	Cytoplasm By similarity. Note: Associated with the membrane possibly through PlsY By similarity.
Sequence similarities	Belongs to the PlsX family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Phosphate acyltransferase HAMAP-Rule MF_00019		PRO_1000193149

Sequences

	Sequence		Length	Mass (Da)
	C1CHD4 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 448D84A40D29947F	FASTA	330	34,849
	10 20 30 40 50 60 MKKIAVDAMG GDYAPQAIVE GVNQALSDFS DIEVQLYGDE AKIKQYLTAT ERVSIIHTDE 70 80 90 100 110 120 KIDSDDEPTR AIRNKKNASM VLAAKAVKDG EADAVLSAGN TGALLAAGFF IVGRIKNIDR 130 140 150 160 170 180 PGLMSTLPTV DGKGFDMLDL GANAENTAQH LHQYAVLGSF YAKNVRGIAQ PRVGLLNNGT 190 200 210 220 230 240 ESSKGDPLRK ETYELLAADE SLNFIGNVEA RDLMNGVADV VVADGFTGNA VLKSIEGTAM 250 260 270 280 290 300 GIMGLLKTAI TGGGLRAKLG ALLLKDSLSG LKKQLNYSDV GGAVLFGVKA PVVKTHGSSD 310 320 330 AKAVYSTIRQ IRTMLETDVV AQTAREFSGE

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain JJA." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JJA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000919 Genomic DNA. Translation: ACO19529.1.
RefSeq	YP_002735177.1. NC_012466.1.
3D structure databases
ProteinModelPortal	C1CHD4.
SMR	C1CHD4. Positions 3-322.
ModBase	Search...
Protein-protein interaction databases
STRING	488222.SPJ_0061.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO19529; ACO19529; SPJ_0061.
GeneID	7680376.
KEGG	sjj:SPJ_0061.
PATRIC	19695150. VBIStrPne71544_0055.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0416.
HOGENOM	HOG000154731.
KO	K03621.
OMA	DEKPSQA.
ProtClustDB	PRK05331.
Enzyme and pathway databases
UniPathway	UPA00085.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
HAMAP	MF_00019. PlsX.
InterPro	IPR003664. FA_synthesis. IPR024084. IsoPropMal-DH-like_dom. IPR012281. Phospholipid_synth_PlsX-like. [Graphical view]
Pfam	PF02504. FA_synthesis. 1 hit. [Graphical view]
PIRSF	PIRSF002465. Phsphlp_syn_PlsX. 1 hit.
TIGRFAMs	TIGR00182. plsX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSX_STRZJ

Accession

Primary (citable) accession number: C1CHD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program