ID   C1CFR2_STRZJ            Unreviewed;       942 AA.
AC   C1CFR2;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=SPJ_1586 {ECO:0000313|EMBL:ACO19629.1};
OS   Streptococcus pneumoniae (strain JJA).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488222 {ECO:0000313|EMBL:ACO19629.1, ECO:0000313|Proteomes:UP000002206};
RN   [1] {ECO:0000313|Proteomes:UP000002206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JJA {ECO:0000313|Proteomes:UP000002206};
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP000919; ACO19629.1; -; Genomic_DNA.
DR   AlphaFoldDB; C1CFR2; -.
DR   KEGG; sjj:SPJ_1586; -.
DR   HOGENOM; CLU_002070_0_0_9; -.
DR   Proteomes; UP000002206; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE   3: Inferred from homology;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Secreted {ECO:0000256|ARBA:ARBA00022512};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          910..942
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          10..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   942 AA;  104481 MW;  8E49F9C126430B76 CRC64;
     MIVGAVVFGT SPVLAQEGAS EQPLANETQL SGESSTLTDT EKSQPSSETE LSGNNQEQER
     KDKQEEKIPR DYYARDLENV ETVIEKEDVE TNASNGQRVD LSSELDKLKK LENATVHMEF
     KPDAKAPAFY NLFSVSSATK KDEYFTMAVY NNTATLEGRG SDGKQFYNNY NDAPLKVKPG
     QWNSVTFTVE KPTAELPKGR VRLYVNGVLS RTSLRSGNFI KDMPDVTHVQ IGATKRANNT
     VWGSNLQIRN LTVYNRALTP EEVQKRSQLF KRSDLEKKLP EGAALTEKTD IFESGRNGNP
     NKDGIKSYRI PALLKTDKGT LIAGADERRL HSSDWGDIGM VIRRSEDNGK TWGDRVTITN
     LRDNPKASDP SIGSPVNIDM VLVQDPETKR IFSIYDMFPE GKGIFGMSSQ KEEAYKKIDG
     KTYQILYREG EKGAYTIREN GTVYTPDGKA TDYRVVVDPV KPAYSDKGDL YKGNQLLGNI
     YFTTNKTSPF RIAKDSYLWM SYSDDDGKTW SAPQDITPMV KADWMKFLGV GPGTGIVLRN
     GPHKGRILIP VYTTNNVSHL NGSQSSRVIY SDDHGKTWHA GEAVNDNRQV DGQKIHSSTM
     NNKRAQNTES TVVQLNNGDV KLFMRGLTGD LQVATSKDGG VTWEKDIKRY PQVKDVYVQM
     SAIHTMHEGK EYIILSNAGG PKRENGMVHL ARVEENGELT WLKHNPIQKG EFAYNSLQEL
     GNGEYGILYE HTEKGQNAYT LSFRKFNWDF LSKDLISPTE AKVKRTREMG KGEMGKGVIG
     LEFDSEVLVN KDPTLQLANG KTATFLTQYD SKTLLFAVDK EDIGQEIIGI AKGSIESMHN
     LPVNLAGARV PGGVNGSKAA VHEVPEFTGG VNGTEPAVHE IAEYKGSDSL VTLTTKEDYT
     YKAPLAQQAL PETGNKESDL LASLGLTAFF LGLFTLGKKR EQ
//