ID   C1CET1_STRZJ            Unreviewed;       740 AA.
AC   C1CET1;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Sialidase B (Neuraminidase B) {ECO:0000313|EMBL:ACO20071.1};
DE            EC=3.2.1.18 {ECO:0000313|EMBL:ACO20071.1};
GN   OrderedLocusNames=SPJ_1242 {ECO:0000313|EMBL:ACO20071.1};
OS   Streptococcus pneumoniae (strain JJA).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488222 {ECO:0000313|EMBL:ACO20071.1, ECO:0000313|Proteomes:UP000002206};
RN   [1] {ECO:0000313|Proteomes:UP000002206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JJA {ECO:0000313|Proteomes:UP000002206};
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP000919; ACO20071.1; -; Genomic_DNA.
DR   RefSeq; WP_000739356.1; NC_012466.1.
DR   AlphaFoldDB; C1CET1; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; sjj:SPJ_1242; -.
DR   HOGENOM; CLU_024974_0_0_9; -.
DR   Proteomes; UP000002206; Chromosome.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR002860; BNR_rpt.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR004124; Glyco_hydro_33_N.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF02012; BNR; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02973; Sialidase; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:ACO20071.1};
KW   Hydrolase {ECO:0000313|EMBL:ACO20071.1}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..740
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002905690"
FT   DOMAIN          98..269
FT                   /note="Glycoside hydrolase family 33 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02973"
FT   DOMAIN          500..703
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
FT   REGION          46..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  82464 MW;  FB80DE12349A72E8 CRC64;
     MKKNIKQYVT LGTVVVLSAF VANLVAAQET ETSEVSTPKL VQPVAPTTPI SEVQPTSDNS
     SEVTVQPRTV ETTVKDPSST AEETPVLEKN NVTLTGGGEN VTKELKDKFT SGDFTVVIKY
     NQSSEKGLQA LFGISNSKPG QQNSYVDVFL RDNGELGMEA RDTSSNKNNL VSRPASVWGK
     YKQEAVTNTV AVVADSVKKT YSLYANGTKV VEKKVDNFLN IKDIKGIDYY MLGGVKRAGK
     TAFGFNGTLE NIKFFNSALD EETVKKMTTN AVTGHLIYTA NDTTGSNYFR IPVLYTFSNG
     RVFSSIDARY GGTHDFLNKI NIATSYSDDN GKTWTKPKLT LAFDDFAPVP LEWPREVGGR
     DLQISGGATY IDSVIVEKKN KQVLMFADVM PAGVSFREAT RKDSGYKQID GNYYLKLRKQ
     GDTDYNYTIR ENGTVYDDRT NRPTEFSVDK NFGIKQNGNY LTVEQYSVSF ENNKKTEYRN
     GTKVHMNIFY KDALFKVVPT NYIAYISSND HGESWSAPTL LPPIMGLNRN APYLGPGRGI
     IESSTGRILI PSYTGKESAF IYSDDNGASW KVKVVPLPSS WSAEAQFVEL SPGVIQAYMR
     TNNGKIAYLT SKDAGTTWSA PEYLKFVSNP SYGTQLSIIN YSQLIDGKKA VILSTPNSTN
     GRKHGQIWIG LINDDNTIDW RYHHDVDYSN YGYSYSTLTE LPNHEIGLMF EKFDSWSRNE
     LHMKNVVPYI TFKIEDLKKN
//