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C1CEM5 (ISPD_STRZJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
MEP cytidylyltransferase
Short name=MCT
Gene names
Name:ispD
Ordered Locus Names:SPJ_1185
OrganismStreptococcus pneumoniae (strain JJA) [Complete proteome] [HAMAP]
Taxonomic identifier488222 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2352352-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
PRO_1000191073

Sites

Site141Transition state stabilizer By similarity
Site221Transition state stabilizer By similarity
Site1611Positions MEP for the nucleophilic attack By similarity
Site2181Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CEM5 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: FA379CEFE2786B21

FASTA23526,256
        10         20         30         40         50         60 
MIYAGILAGG TGTRMGISNL PKQFLELGDR PILIHTIEKF VLEPSIEKIV VGVHGDWVSH 

        70         80         90        100        110        120 
AEDLVDKYLP LYKERIIITK GGADRNTSIK KIIEAIDAYR PLTPEDIVVT HDSVRPFITL 

       130        140        150        160        170        180 
RMIQDNIQLA QNHDAVDTVV EAVDTIVEST NGQFITDIPN RAHLYQGQTP QTFRCKDFMD 

       190        200        210        220        230 
LYGSLSDEEK EILTDACKIF VIKGKDVALA KGEYSNLKIT TVTDLKIAKS MIEKD

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain JJA."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JJA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000919 Genomic DNA. Translation: ACO19595.1.
RefSeqYP_002736246.1. NC_012466.1.

3D structure databases

ProteinModelPortalC1CEM5.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1CEM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000075324; EBSTRP00000071705; EBSTRG00000076892.
GeneID7679302.
GenomeReviewsGene locus SPJ_1185 in contig CP000919_GR.
KEGGsjj:SPJ_1185.
PATRIC19697526. VBIStrPne71544_1242.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027822.
OMAGELFNIK.
ProtClustDBPRK00155.

Enzyme and pathway databases

BioCycSPNE1313:SPJ_1185-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD_STRZJ
AccessionPrimary (citable) accession number: C1CEM5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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