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C1CEK4

- RNC_STRZJ

UniProt

C1CEK4 - RNC_STRZJ

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Protein

Ribonuclease 3

Gene

rnc

Organism
Streptococcus pneumoniae (strain JJA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471MagnesiumUniRule annotation
Active sitei51 – 511UniRule annotation
Metal bindingi120 – 1201MagnesiumUniRule annotation
Active sitei123 – 1231UniRule annotation
Metal bindingi123 – 1231MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciSPNE488222:GI12-1138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:SPJ_1161
OrganismiStreptococcus pneumoniae (strain JJA)
Taxonomic identifieri488222 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002206: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Ribonuclease 3PRO_1000118937Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi488222.SPJ_1161.

Structurei

3D structure databases

ProteinModelPortaliC1CEK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 134130RNase IIIUniRule annotationAdd
BLAST
Domaini160 – 22970DRBMUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
Contains 1 RNase III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0571.
HOGENOMiHOG000246808.
KOiK03685.
OMAiNIHGNIF.
OrthoDBiEOG6T1WVS.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CEK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKELQTVLKN HFAIEFTDKK LLETAFTHTS YANEHRLLKI SHNERLEFLG
60 70 80 90 100
DAVLQLLISE YLYKKYPKKP EGDLSKLRAM IVREESLAGF ARDCQFDQFI
110 120 130 140 150
KLGKGEEKSG GRNRDTILGD AFEAFLGALL LDKDVAKVKE FIYQVMIPKV
160 170 180 190 200
EAGEFEMITD YKTHLQELLQ VNGDVAIRYQ VISETGPAHD KVFDVEVLVE
210 220 230
GKSIGQGQGR SKKLAEQEAA KNAVEKGLDS CI
Length:232
Mass (Da):26,198
Last modified:May 26, 2009 - v1
Checksum:i8E6C3E4E620D0345
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000919 Genomic DNA. Translation: ACO18707.1.
RefSeqiYP_002736225.1. NC_012466.1.

Genome annotation databases

EnsemblBacteriaiACO18707; ACO18707; SPJ_1161.
GeneIDi7678593.
KEGGisjj:SPJ_1161.
PATRICi19697476. VBIStrPne71544_1218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000919 Genomic DNA. Translation: ACO18707.1 .
RefSeqi YP_002736225.1. NC_012466.1.

3D structure databases

ProteinModelPortali C1CEK4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 488222.SPJ_1161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO18707 ; ACO18707 ; SPJ_1161 .
GeneIDi 7678593.
KEGGi sjj:SPJ_1161.
PATRICi 19697476. VBIStrPne71544_1218.

Phylogenomic databases

eggNOGi COG0571.
HOGENOMi HOG000246808.
KOi K03685.
OMAi NIHGNIF.
OrthoDBi EOG6T1WVS.

Enzyme and pathway databases

BioCyci SPNE488222:GI12-1138-MONOMER.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain JJA."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JJA.

Entry informationi

Entry nameiRNC_STRZJ
AccessioniPrimary (citable) accession number: C1CEK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3