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Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus pneumoniae (strain JJA)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease, Helicase, Hydrolase
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:SPJ_1152
OrganismiStreptococcus pneumoniae (strain JJA)
Taxonomic identifieri488222 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002206 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002005551 – 662UvrABC system protein BAdd BLAST662

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC1CEJ5.
SMRiC1CEJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 188Helicase ATP-bindingUniRule annotationAdd BLAST158
Domaini435 – 601Helicase C-terminalUniRule annotationAdd BLAST167
Domaini626 – 661UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073580.
KOiK03702.
OMAiRYMHSEI.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

C1CEJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINHITDNQF KLVSKYQPSG DQPQAIEQLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVISK VNKPTLVIAH NKTLAGQLYG EFKEFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYA DSVVSLRPGL EISRDKLLND LVDIQFERND IDFQRGRFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EVEALTGQVL GEVDHLAIFP
260 270 280 290 300
ATHFVTNDDH MEVAIAKIQA ELEEQLAVFE KEGKLLEAQR LKQRTEYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPDDFLI MIDESHMTIG
360 370 380 390 400
QIKGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYENEQTE TVIEQIIRPT GLLDPEVEVR PTMGQIDDLL GEINARVEKN
460 470 480 490 500
ERTFITTLTK KMAEDLTDYF KEMGIKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLVGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADT VTQSMQRAID ETARRRKIQM AYNEEHGIVP QTIKKEIRDL
610 620 630 640 650
IAVTKAVAKE EDKEVDINSL NKQERKELVK KLEKQMQEAV EVLDFELAAQ
660
IRDMMLEVKA LD
Length:662
Mass (Da):75,734
Last modified:May 26, 2009 - v1
Checksum:iC2EB617ED537BDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000919 Genomic DNA. Translation: ACO18838.1.
RefSeqiWP_000607027.1. NC_012466.1.

Genome annotation databases

EnsemblBacteriaiACO18838; ACO18838; SPJ_1152.
KEGGisjj:SPJ_1152.

Similar proteinsi

Entry informationi

Entry nameiUVRB_STRZJ
AccessioniPrimary (citable) accession number: C1CEJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families