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C1CE02 (PEPT_STRZJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidase T

EC=3.4.11.4
Alternative name(s):
Aminotripeptidase
Short name=Tripeptidase
Tripeptide aminopeptidase
Gene names
Name:pepT
Ordered Locus Names:SPJ_0948
OrganismStreptococcus pneumoniae (strain JJA) [Complete proteome] [HAMAP]
Taxonomic identifier488222 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves the N-terminal amino acid of tripeptides By similarity. HAMAP-Rule MF_00550

Catalytic activity

Release of the N-terminal residue from a tripeptide. HAMAP-Rule MF_00550

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_00550

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00550.

Sequence similarities

Belongs to the peptidase M20B family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionAminopeptidase
Hydrolase
Metalloprotease
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpeptide metabolic process

Inferred from electronic annotation. Source: InterPro

proteolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetallopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

tripeptide aminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Peptidase T HAMAP-Rule MF_00550
PRO_1000200901

Sites

Active site831 By similarity
Active site1761Proton acceptor By similarity
Metal binding811Zinc 1 By similarity
Metal binding1421Zinc 1 By similarity
Metal binding1421Zinc 2 By similarity
Metal binding1771Zinc 2 By similarity
Metal binding1991Zinc 1 By similarity
Metal binding3811Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CE02 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 8A3C0DD750881344

FASTA40744,833
        10         20         30         40         50         60 
MTYPNLLDRF LTYVKVNTRS DEHSTTTPST QSQVDFATNV LIPEMKRVGL QNVYYLPNGF 

        70         80         90        100        110        120 
AIGTLPANDP SLTRKIGFIS HMDTADFNAE GVNPQVIENY DGGVIELGNS GFKLDPADFK 

       130        140        150        160        170        180 
SLEKYPGQTL ITTDGTSLLG ADDKSGIAEI MTTIEYLTAH PEIKHCEIRV GFGPDEEIGV 

       190        200        210        220        230        240 
GANKFDAEDF DVDFAYTVDG GPLGELQYET FSAAGAELHF QGRNVHPGTA KGQMVNALQL 

       250        260        270        280        290        300 
AIDFHNQLPE NDRPELTEGY QGFYHLMDVT GSVEEVRASY IIRDFEKDAF EARKASMQSI 

       310        320        330        340        350        360 
ADKMNEELGS DRVTLNLTDQ YYNMKEVIEK DMTPITIAKA VMEDLGITPI IEPIRGGTDG 

       370        380        390        400 
SKISFMGIPT PNIFAGGENM HGRFEYVSLQ TMERAVDTII GIVAYKG 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain JJA."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JJA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000919 Genomic DNA. Translation: ACO20120.1.
RefSeqYP_002736023.1. NC_012466.1.

3D structure databases

ProteinModelPortalC1CE02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING488222.SPJ_0948.

Protein family/group databases

MEROPSM20.003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO20120; ACO20120; SPJ_0948.
GeneID7678667.
KEGGsjj:SPJ_0948.
PATRIC19697044. VBIStrPne71544_1004.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2195.
HOGENOMHOG000032390.
KOK01258.
OMAYVYATIP.
OrthoDBEOG6SV59Q.
ProtClustDBPRK05469.

Enzyme and pathway databases

BioCycSPNE488222:GI12-930-MONOMER.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
HAMAPMF_00550. Aminopeptidase_M20.
InterProIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMSSF55031. SSF55031. 1 hit.
TIGRFAMsTIGR01882. peptidase-T. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePEPT_STRZJ
AccessionPrimary (citable) accession number: C1CE02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries