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C1CE02

- PEPT_STRZJ

UniProt

C1CE02 - PEPT_STRZJ

Protein

Peptidase T

Gene

pepT

Organism
Streptococcus pneumoniae (strain JJA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Zinc 1UniRule annotation
    Active sitei83 – 831UniRule annotation
    Metal bindingi142 – 1421Zinc 1UniRule annotation
    Metal bindingi142 – 1421Zinc 2UniRule annotation
    Active sitei176 – 1761Proton acceptorUniRule annotation
    Metal bindingi177 – 1771Zinc 2UniRule annotation
    Metal bindingi199 – 1991Zinc 1UniRule annotation
    Metal bindingi381 – 3811Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSPNE488222:GI12-930-MONOMER.

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:SPJ_0948
    OrganismiStreptococcus pneumoniae (strain JJA)
    Taxonomic identifieri488222 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002206: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Peptidase TPRO_1000200901Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi488222.SPJ_0948.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CE02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiHENYDGE.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CE02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYPNLLDRF LTYVKVNTRS DEHSTTTPST QSQVDFATNV LIPEMKRVGL    50
    QNVYYLPNGF AIGTLPANDP SLTRKIGFIS HMDTADFNAE GVNPQVIENY 100
    DGGVIELGNS GFKLDPADFK SLEKYPGQTL ITTDGTSLLG ADDKSGIAEI 150
    MTTIEYLTAH PEIKHCEIRV GFGPDEEIGV GANKFDAEDF DVDFAYTVDG 200
    GPLGELQYET FSAAGAELHF QGRNVHPGTA KGQMVNALQL AIDFHNQLPE 250
    NDRPELTEGY QGFYHLMDVT GSVEEVRASY IIRDFEKDAF EARKASMQSI 300
    ADKMNEELGS DRVTLNLTDQ YYNMKEVIEK DMTPITIAKA VMEDLGITPI 350
    IEPIRGGTDG SKISFMGIPT PNIFAGGENM HGRFEYVSLQ TMERAVDTII 400
    GIVAYKG 407
    Length:407
    Mass (Da):44,833
    Last modified:May 26, 2009 - v1
    Checksum:i8A3C0DD750881344
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000919 Genomic DNA. Translation: ACO20120.1.
    RefSeqiYP_002736023.1. NC_012466.1.

    Genome annotation databases

    EnsemblBacteriaiACO20120; ACO20120; SPJ_0948.
    GeneIDi7678667.
    KEGGisjj:SPJ_0948.
    PATRICi19697044. VBIStrPne71544_1004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000919 Genomic DNA. Translation: ACO20120.1 .
    RefSeqi YP_002736023.1. NC_012466.1.

    3D structure databases

    ProteinModelPortali C1CE02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 488222.SPJ_0948.

    Protein family/group databases

    MEROPSi M20.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO20120 ; ACO20120 ; SPJ_0948 .
    GeneIDi 7678667.
    KEGGi sjj:SPJ_0948.
    PATRICi 19697044. VBIStrPne71544_1004.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi HENYDGE.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci SPNE488222:GI12-930-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain JJA."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JJA.

    Entry informationi

    Entry nameiPEPT_STRZJ
    AccessioniPrimary (citable) accession number: C1CE02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3