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C1CE02

- PEPT_STRZJ

UniProt

C1CE02 - PEPT_STRZJ

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Protein

Peptidase T

Gene

pepT

Organism
Streptococcus pneumoniae (strain JJA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn(2+) ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Zinc 1UniRule annotation
Active sitei83 – 831UniRule annotation
Metal bindingi142 – 1421Zinc 1UniRule annotation
Metal bindingi142 – 1421Zinc 2UniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation
Metal bindingi177 – 1771Zinc 2UniRule annotation
Metal bindingi199 – 1991Zinc 1UniRule annotation
Metal bindingi381 – 3811Zinc 2UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPNE488222:GI12-930-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:SPJ_0948
OrganismiStreptococcus pneumoniae (strain JJA)
Taxonomic identifieri488222 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002206: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Peptidase TPRO_1000200901Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi488222.SPJ_0948.

Structurei

3D structure databases

ProteinModelPortaliC1CE02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiHENYDGE.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1CE02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYPNLLDRF LTYVKVNTRS DEHSTTTPST QSQVDFATNV LIPEMKRVGL
60 70 80 90 100
QNVYYLPNGF AIGTLPANDP SLTRKIGFIS HMDTADFNAE GVNPQVIENY
110 120 130 140 150
DGGVIELGNS GFKLDPADFK SLEKYPGQTL ITTDGTSLLG ADDKSGIAEI
160 170 180 190 200
MTTIEYLTAH PEIKHCEIRV GFGPDEEIGV GANKFDAEDF DVDFAYTVDG
210 220 230 240 250
GPLGELQYET FSAAGAELHF QGRNVHPGTA KGQMVNALQL AIDFHNQLPE
260 270 280 290 300
NDRPELTEGY QGFYHLMDVT GSVEEVRASY IIRDFEKDAF EARKASMQSI
310 320 330 340 350
ADKMNEELGS DRVTLNLTDQ YYNMKEVIEK DMTPITIAKA VMEDLGITPI
360 370 380 390 400
IEPIRGGTDG SKISFMGIPT PNIFAGGENM HGRFEYVSLQ TMERAVDTII

GIVAYKG
Length:407
Mass (Da):44,833
Last modified:May 26, 2009 - v1
Checksum:i8A3C0DD750881344
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000919 Genomic DNA. Translation: ACO20120.1.
RefSeqiYP_002736023.1. NC_012466.1.

Genome annotation databases

EnsemblBacteriaiACO20120; ACO20120; SPJ_0948.
GeneIDi7678667.
KEGGisjj:SPJ_0948.
PATRICi19697044. VBIStrPne71544_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000919 Genomic DNA. Translation: ACO20120.1 .
RefSeqi YP_002736023.1. NC_012466.1.

3D structure databases

ProteinModelPortali C1CE02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 488222.SPJ_0948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO20120 ; ACO20120 ; SPJ_0948 .
GeneIDi 7678667.
KEGGi sjj:SPJ_0948.
PATRICi 19697044. VBIStrPne71544_1004.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
KOi K01258.
OMAi HENYDGE.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci SPNE488222:GI12-930-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain JJA."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JJA.

Entry informationi

Entry nameiPEPT_STRZJ
AccessioniPrimary (citable) accession number: C1CE02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3