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C1CDT9 (TRMFO_STRZJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
EC=2.1.1.74
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene names
Name:trmFO
Ordered Locus Names:SPJ_0882
OrganismStreptococcus pneumoniae (strain JJA) [Complete proteome] [HAMAP]
Taxonomic identifier488222 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity. HAMAP-Rule MF_01037

Catalytic activity

5,10-methylenetetrahydrofolate + uridine54 in tRNA + FADH2 = tetrahydrofolate + 5-methyluridine54 in tRNA + FAD. HAMAP-Rule MF_01037

Cofactor

FAD By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MnmG family. TrmFO subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO HAMAP-Rule MF_01037
PRO_1000149480

Regions

Nucleotide binding10 – 156FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C1CDT9 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: F72524DED4F0F593

FASTA44449,300
        10         20         30         40         50         60 
MSQSYINVIG AGLAGSEAAY QIAERGIPVK LYEMRGVKST PQHKTDNFAE LVCSNSLRGD 

        70         80         90        100        110        120 
ALTNAVGLLK EEMRRLGSVI LESAEATRVP AGGALAVDRD GFSQMVTEKV VNHPLIEVVR 

       130        140        150        160        170        180 
DEITELPTDV ITVVATGPLT SDALAEKIHA LNNGDGFYFY DAAAPIIDVN TIDMSKVYLK 

       190        200        210        220        230        240 
SRYDKGEAAY LNAPMTKQEF MDFHEALVNA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT 

       250        260        270        280        290        300 
MLYGPMKPVG LEYPDDYTGP RDGEFKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR 

       310        320        330        340        350        360 
VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LEQTYRSKKQ PNLFFAGQMT GVEGYVESAA 

       370        380        390        400        410        420 
SGLVAGINAA RLFKEESEVI FPETTAIGSL AHYITHADSK HFQPMNVNFG IIKELEGERI 

       430        440 
RDKKARYEKI AERALADLEE FLTV

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain JJA."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JJA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000919 Genomic DNA. Translation: ACO19789.1.
RefSeqYP_002735960.1. NC_012466.1.

3D structure databases

ProteinModelPortalC1CDT9.
ModBaseSearch...

Protein-protein interaction databases

STRING488222.SPJ_0882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO19789; ACO19789; SPJ_0882.
GeneID7680137.
KEGGsjj:SPJ_0882.
PATRIC19696906. VBIStrPne71544_0934.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1206.
HOGENOMHOG000252054.
KOK04094.
OMARFAGQIT.
ProtClustDBPRK05335.

Family and domain databases

HAMAPMF_01037. TrmFO.
InterProIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00137. gid_trmFO. 1 hit.
PROSITEPS01280. GIDA_1. False negative.
PS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMFO_STRZJ
AccessionPrimary (citable) accession number: C1CDT9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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