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C1CDT9

- TRMFO_STRZJ

UniProt

C1CDT9 - TRMFO_STRZJ

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Streptococcus pneumoniae (strain JJA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciSPNE488222:GI12-866-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmFOUniRule annotation
    Ordered Locus Names:SPJ_0882
    OrganismiStreptococcus pneumoniae (strain JJA)
    Taxonomic identifieri488222 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002206: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_1000149480Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi488222.SPJ_0882.

    Structurei

    3D structure databases

    ProteinModelPortaliC1CDT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
    PROSITEiPS01281. GIDA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1CDT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSYINVIG AGLAGSEAAY QIAERGIPVK LYEMRGVKST PQHKTDNFAE    50
    LVCSNSLRGD ALTNAVGLLK EEMRRLGSVI LESAEATRVP AGGALAVDRD 100
    GFSQMVTEKV VNHPLIEVVR DEITELPTDV ITVVATGPLT SDALAEKIHA 150
    LNNGDGFYFY DAAAPIIDVN TIDMSKVYLK SRYDKGEAAY LNAPMTKQEF 200
    MDFHEALVNA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT MLYGPMKPVG 250
    LEYPDDYTGP RDGEFKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR 300
    VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LEQTYRSKKQ PNLFFAGQMT 350
    GVEGYVESAA SGLVAGINAA RLFKEESEVI FPETTAIGSL AHYITHADSK 400
    HFQPMNVNFG IIKELEGERI RDKKARYEKI AERALADLEE FLTV 444
    Length:444
    Mass (Da):49,300
    Last modified:May 26, 2009 - v1
    Checksum:iF72524DED4F0F593
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000919 Genomic DNA. Translation: ACO19789.1.
    RefSeqiYP_002735960.1. NC_012466.1.

    Genome annotation databases

    EnsemblBacteriaiACO19789; ACO19789; SPJ_0882.
    GeneIDi7680137.
    KEGGisjj:SPJ_0882.
    PATRICi19696906. VBIStrPne71544_0934.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000919 Genomic DNA. Translation: ACO19789.1 .
    RefSeqi YP_002735960.1. NC_012466.1.

    3D structure databases

    ProteinModelPortali C1CDT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 488222.SPJ_0882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO19789 ; ACO19789 ; SPJ_0882 .
    GeneIDi 7680137.
    KEGGi sjj:SPJ_0882.
    PATRICi 19696906. VBIStrPne71544_0934.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci SPNE488222:GI12-866-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR020595. GIDA-rel_CS.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    PROSITEi PS01281. GIDA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain JJA."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JJA.

    Entry informationi

    Entry nameiTRMFO_STRZJ
    AccessioniPrimary (citable) accession number: C1CDT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3