C1CB02 (FUCI_STRP7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-fucose isomerase
EC=5.3.1.25

Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase

Gene names

Name:	fucI
Ordered Locus Names:	SP70585_2284

Organism

Streptococcus pneumoniae (strain 70585) [Complete proteome] [HAMAP]

Taxonomic identifier

488221 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254
Catalytic activity	L-fucose = L-fuculose. HAMAP-Rule MF_01254
Cofactor	Manganese By similarity.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the L-fucose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fucose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	L-fucose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	L-fucose isomerase HAMAP-Rule MF_01254		PRO_1000165097
Sites
	Active site	335	1	Proton acceptor By similarity
	Active site	359	1	Proton acceptor By similarity
	Metal binding	335	1	Manganese By similarity
	Metal binding	359	1	Manganese By similarity
	Metal binding	525	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1CB02 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 1FD5AD32CA1A4DED	FASTA	588	65,877
	10 20 30 40 50 60 MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP VECVISPSTI 70 80 90 100 110 120 GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD IPHAIWGFNG TERPGAVYLA 130 140 150 160 170 180 AVLASHAQKG IPAFGIYGRD VQEANDTDIP EDVKEKLLRY ARAALATGLM RDTAYLSMGS 190 200 210 220 230 240 VSMGIGGSIV NPDFFQEYLG MRNESVDMTE FTRRMDRGIY DPEEFERAMV WVKEHIKEGV 250 260 270 280 290 300 DRNREDLILS KEEKEKQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 310 320 330 340 350 360 RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL TNTPQIFADV 370 380 390 400 410 420 RTYWSPEAVK RVTGHTLEGR AAAGFLHLIN SGSCTLDGTG QATRDGKPVM KPFWELEESE 430 440 450 460 470 480 VQAMLENTDF PPANREYFRG GGFSTRFLTK GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL 490 500 510 520 530 540 PEDVHHTLDN RTDPGWPTTW FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL 550 560 570 580 ASMLRIPVNM HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK

References

[1]	"Complete genome sequence of Streptococcus pneumoniae strain 70585." Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70585.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000918 Genomic DNA. Translation: ACO17577.1.
RefSeq	YP_002741440.1. NC_012468.1.
3D structure databases
ProteinModelPortal	C1CB02.
SMR	C1CB02. Positions 2-588.
ModBase	Search...
Protein-protein interaction databases
STRING	488221.SP70585_2284.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACO17577; ACO17577; SP70585_2284.
GeneID	7683059.
KEGG	snm:SP70585_2284.
PATRIC	19671012. VBIStrPne83895_2315.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2407.
HOGENOM	HOG000249674.
KO	K01818.
OMA	KIGIRPT.
ProtClustDB	PRK10991.
Enzyme and pathway databases
UniPathway	UPA00563; UER00624.
Family and domain databases
Gene3D	3.20.14.10. 1 hit. 3.40.275.10. 1 hit. 3.40.50.1070. 1 hit.
HAMAP	MF_01254. Fucose_iso.
InterPro	IPR004216. Fuc/Ara_isomerase_C. IPR015888. Fuc_isomerase_C. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR009015. Fucose_isomerase_N/cen. IPR012889. Fucose_isomerase_N2. [Graphical view]
Pfam	PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit. [Graphical view]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
TIGRFAMs	TIGR01089. fucI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCI_STRP7

Accession

Primary (citable) accession number: C1CB02

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program