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C1C7J4 (FTHS_STRP7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:SP70585_1275
OrganismStreptococcus pneumoniae (strain 70585) [Complete proteome] [HAMAP]
Taxonomic identifier488221 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185265

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C1C7J4 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 024307B004FD84CD

FASTA55659,614
        10         20         30         40         50         60 
MKTDIEIAQS IELKPIVDVV EKLGISYDDL ELYGKYKAKL SFDKIRAVES NPVGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KSTLTIGLAD ALNKIGKKTM IAIREPSLGP VMGIKGGAAG GGYAQVLPME 

       130        140        150        160        170        180 
DINLHFTGDM HAITTANNAL SALIDNHLHQ GNELGIDQRR ILWKRVVDLN DRALRHVTVG 

       190        200        210        220        230        240 
LGGPLNGIPR EDGFDITVAS EIMAILCLAT DIEDLKRRLA NIVIGYRYDR TPVSVGDLQV 

       250        260        270        280        290        300 
EGALALILKD AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALH LADYTVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV EAVRAGFANL 

       370        380        390        400        410        420 
KRHVENIRKF GIPAVVAINE FVSDTEAEIA VLKELCASID VPVELASVWA DGAEGGVALA 

       430        440        450        460        470        480 
ETVVKTIAEN PANYKRLYDN DLSVQEKIEK IVTEIYRGSK VNFEKKAQTQ IAQIVQNGWD 

       490        500        510        520        530        540 
KLPICMAKTQ YSFSDNPNAL GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA 

       550 
ALNMDVESDG TVLGLF 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain 70585."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 70585.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000918 Genomic DNA. Translation: ACO15951.1.
RefSeqYP_002740520.1. NC_012468.1.

3D structure databases

ProteinModelPortalC1C7J4.
SMRC1C7J4. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING488221.SP70585_1275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO15951; ACO15951; SP70585_1275.
GeneID7683155.
KEGGsnm:SP70585_1275.
PATRIC19668909. VBIStrPne83895_1318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSPNE488221:GH4U-1245-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_STRP7
AccessionPrimary (citable) accession number: C1C7J4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways