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C1C6D0

- C1C6D0_STRP7

UniProt

C1C6D0 - C1C6D0_STRP7

Protein

Methionine--tRNA ligase

Gene

metG1

Organism
Streptococcus pneumoniae (strain 70585)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi160 – 1601ZincUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSPNE488221:GH4U-816-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
    Alternative name(s):
    Methionyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:metG1Imported
    Synonyms:metGUniRule annotation
    Ordered Locus Names:SP70585_0831Imported
    OrganismiStreptococcus pneumoniae (strain 70585)Imported
    Taxonomic identifieri488221 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002211: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.SAAS annotation
    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi488221.SP70585_0831.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini562 – 665104tRNA-bindingUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi13 – 2311"HIGH" regionUniRule annotationAdd
    BLAST
    Motifi309 – 3135"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation
    Contains 1 tRNA-binding domain.UniRule annotation
    Contains tRNA-binding domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0143.
    HOGENOMiHOG000200401.
    KOiK01874.
    OMAiHPEFVQP.
    OrthoDBiEOG6CVV9B.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_01228. Met_tRNA_synth_type2.
    InterProiIPR004495. Met-tRNA-synth_Ia_bsu_C.
    IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PfamiPF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view]
    PRINTSiPR01041. TRNASYNTHMET.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00398. metG. 1 hit.
    TIGR00399. metG_C_term. 1 hit.
    PROSITEiPS50886. TRBD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1C6D0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKNFYITT PIYYPSGKLH IGSAYTTIAC DVLARYKRLM GYDVFYLTGL    50
    DEHGQKIQQK AEEAGITPQA YVDGMAVGVK ELWQLLDISY DKFIRTTDDY 100
    HEKVVAQVFE RLLAQDDIYL GEYSGWYSVS DEEFFTESQL AEVFRDEAGN 150
    VTGGIAPSGH EVEWVSEESY FLRLSKYQDR LVEFFKAHPE FITPDGRLNE 200
    MLRNFIEPGL EDLAVSRTTF TWGVPVPSNP KHVVYVWIDA LLNYATALGY 250
    AQDEHGNFDK FWNGTVFHMV GKDILRFHSI YWPILLMMLD VKLPDRLIAH 300
    GWFVMKDGKM SKSKGNVVYP EMLVERYGLD PLRYYLMRNL PVGSDGTFTP 350
    EDYVGRINYE LANDLGNLLN RTVSMINKYF DGQIPAYVEG VTEFDHVLAE 400
    VAEQSIADFH THMEAVDYPR ALEAVWTLIS RTNKYIDETA PWVLAKDEAL 450
    RDQLASVMSH LAASIRVVAH LIEPFMMETS RAVLTQLGLE EVSSLENLSL 500
    ADFPADVTVV AKGTPIFPRL NMEEEIAYIK EQMEGNKPAV EKEWNPDAVE 550
    LKLNKDEIKF EDFDKVEIRV AEVKEVSKVE GSDKLLQFRL DAGDGEDRQI 600
    LSGIAKYYPN EQELVGKKVQ IVANLKPRKM MKKYVSQGMI LSAEHDGKLT 650
    LLTVDPAVPN GSVIG 665
    Length:665
    Mass (Da):75,593
    Last modified:May 26, 2009 - v1
    Checksum:iDFAB60A1CC4AB91B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000918 Genomic DNA. Translation: ACO16256.1.
    RefSeqiYP_002740106.1. NC_012468.1.

    Genome annotation databases

    EnsemblBacteriaiACO16256; ACO16256; SP70585_0831.
    GeneIDi7684253.
    KEGGisnm:SP70585_0831.
    PATRICi19667978. VBIStrPne83895_0856.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000918 Genomic DNA. Translation: ACO16256.1 .
    RefSeqi YP_002740106.1. NC_012468.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 488221.SP70585_0831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO16256 ; ACO16256 ; SP70585_0831 .
    GeneIDi 7684253.
    KEGGi snm:SP70585_0831.
    PATRICi 19667978. VBIStrPne83895_0856.

    Phylogenomic databases

    eggNOGi COG0143.
    HOGENOMi HOG000200401.
    KOi K01874.
    OMAi HPEFVQP.
    OrthoDBi EOG6CVV9B.

    Enzyme and pathway databases

    BioCyci SPNE488221:GH4U-816-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    2.40.50.140. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_01228. Met_tRNA_synth_type2.
    InterProi IPR004495. Met-tRNA-synth_Ia_bsu_C.
    IPR014758. Met-tRNA_synth.
    IPR023457. Met-tRNA_synth_2.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR012340. NA-bd_OB-fold.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002547. tRNA-bd_dom.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    Pfami PF09334. tRNA-synt_1g. 1 hit.
    PF01588. tRNA_bind. 1 hit.
    [Graphical view ]
    PRINTSi PR01041. TRNASYNTHMET.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00398. metG. 1 hit.
    TIGR00399. metG_C_term. 1 hit.
    PROSITEi PS50886. TRBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Streptococcus pneumoniae strain 70585."
      Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70585Imported.

    Entry informationi

    Entry nameiC1C6D0_STRP7
    AccessioniPrimary (citable) accession number: C1C6D0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3