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C1C6D0 (C1C6D0_STRP7) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine--tRNA ligase HAMAP-Rule MF_01228

EC=6.1.1.10 HAMAP-Rule MF_01228
Alternative name(s):
Methionyl-tRNA synthetase HAMAP-Rule MF_01228
Gene names
Name:metG1 EMBL ACO16256.1
Synonyms:metG HAMAP-Rule MF_01228
Ordered Locus Names:SP70585_0831 EMBL ACO16256.1
OrganismStreptococcus pneumoniae (strain 70585) [Complete proteome] [HAMAP] EMBL ACO16256.1
Taxonomic identifier488221 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length665 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity. HAMAP-Rule MF_01228 SAAS SAAS014758

Catalytic activity

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). HAMAP-Rule MF_01228 SAAS SAAS023457

Subunit structure

Homodimer By similarity. SAAS SAAS014758

Monomer By similarity. HAMAP-Rule MF_01228

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01228 SAAS SAAS014758.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. HAMAP-Rule MF_01228

Contains 1 tRNA-binding domain. HAMAP-Rule MF_01228

Contains tRNA-binding domain. SAAS SAAS014758

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain562 – 665104tRNA-binding By similarity HAMAP-Rule MF_01228
Motif13 – 2311"HIGH" region By similarity HAMAP-Rule MF_01228
Motif309 – 3135"KMSKS" region By similarity HAMAP-Rule MF_01228

Sites

Metal binding1601Zinc By similarity HAMAP-Rule MF_01228

Sequences

Sequence LengthMass (Da)Tools
C1C6D0 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: DFAB60A1CC4AB91B

FASTA66575,593
        10         20         30         40         50         60 
MSEKNFYITT PIYYPSGKLH IGSAYTTIAC DVLARYKRLM GYDVFYLTGL DEHGQKIQQK 

        70         80         90        100        110        120 
AEEAGITPQA YVDGMAVGVK ELWQLLDISY DKFIRTTDDY HEKVVAQVFE RLLAQDDIYL 

       130        140        150        160        170        180 
GEYSGWYSVS DEEFFTESQL AEVFRDEAGN VTGGIAPSGH EVEWVSEESY FLRLSKYQDR 

       190        200        210        220        230        240 
LVEFFKAHPE FITPDGRLNE MLRNFIEPGL EDLAVSRTTF TWGVPVPSNP KHVVYVWIDA 

       250        260        270        280        290        300 
LLNYATALGY AQDEHGNFDK FWNGTVFHMV GKDILRFHSI YWPILLMMLD VKLPDRLIAH 

       310        320        330        340        350        360 
GWFVMKDGKM SKSKGNVVYP EMLVERYGLD PLRYYLMRNL PVGSDGTFTP EDYVGRINYE 

       370        380        390        400        410        420 
LANDLGNLLN RTVSMINKYF DGQIPAYVEG VTEFDHVLAE VAEQSIADFH THMEAVDYPR 

       430        440        450        460        470        480 
ALEAVWTLIS RTNKYIDETA PWVLAKDEAL RDQLASVMSH LAASIRVVAH LIEPFMMETS 

       490        500        510        520        530        540 
RAVLTQLGLE EVSSLENLSL ADFPADVTVV AKGTPIFPRL NMEEEIAYIK EQMEGNKPAV 

       550        560        570        580        590        600 
EKEWNPDAVE LKLNKDEIKF EDFDKVEIRV AEVKEVSKVE GSDKLLQFRL DAGDGEDRQI 

       610        620        630        640        650        660 
LSGIAKYYPN EQELVGKKVQ IVANLKPRKM MKKYVSQGMI LSAEHDGKLT LLTVDPAVPN 


GSVIG 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain 70585."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 70585.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000918 Genomic DNA. Translation: ACO16256.1.
RefSeqYP_002740106.1. NC_012468.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING488221.SP70585_0831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO16256; ACO16256; SP70585_0831.
GeneID7684253.
KEGGsnm:SP70585_0831.
PATRIC19667978. VBIStrPne83895_0856.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0143.
HOGENOMHOG000200401.
KOK01874.
OMAHPEFVQP.
OrthoDBEOG6CVV9B.

Enzyme and pathway databases

BioCycSPNE488221:GH4U-816-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_01228. Met_tRNA_synth_type2.
InterProIPR004495. Met-tRNA-synth_Ia_bsu_C.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamPF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
PRINTSPR01041. TRNASYNTHMET.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00398. metG. 1 hit.
TIGR00399. metG_C_term. 1 hit.
PROSITEPS50886. TRBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC1C6D0_STRP7
AccessionPrimary (citable) accession number: C1C6D0
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)