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C1C6D0

- C1C6D0_STRP7

UniProt

C1C6D0 - C1C6D0_STRP7

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Protein
Methionine--tRNA ligase
Gene
metG1, metG, SP70585_0831
Organism
Streptococcus pneumoniae (strain 70585)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi160 – 1601Zinc By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationsImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding, RNA-binding, tRNA-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSPNE488221:GH4U-816-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetase
Gene namesi
Name:metG1Imported
Synonyms:metGUniRule annotation
Ordered Locus Names:SP70585_0831Imported
OrganismiStreptococcus pneumoniae (strain 70585)Imported
Taxonomic identifieri488221 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002211: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.SAAS annotations
Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi488221.SP70585_0831.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 665104tRNA-binding By similarityUniRule annotation
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi13 – 2311"HIGH" region By similarityUniRule annotation
Add
BLAST
Motifi309 – 3135"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Contains 1 tRNA-binding domain.UniRule annotation
Contains tRNA-binding domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200401.
KOiK01874.
OMAiHPEFVQP.
OrthoDBiEOG6CVV9B.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_01228. Met_tRNA_synth_type2.
InterProiIPR004495. Met-tRNA-synth_Ia_bsu_C.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
TIGR00399. metG_C_term. 1 hit.
PROSITEiPS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1C6D0-1 [UniParc]FASTAAdd to Basket

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MSEKNFYITT PIYYPSGKLH IGSAYTTIAC DVLARYKRLM GYDVFYLTGL    50
DEHGQKIQQK AEEAGITPQA YVDGMAVGVK ELWQLLDISY DKFIRTTDDY 100
HEKVVAQVFE RLLAQDDIYL GEYSGWYSVS DEEFFTESQL AEVFRDEAGN 150
VTGGIAPSGH EVEWVSEESY FLRLSKYQDR LVEFFKAHPE FITPDGRLNE 200
MLRNFIEPGL EDLAVSRTTF TWGVPVPSNP KHVVYVWIDA LLNYATALGY 250
AQDEHGNFDK FWNGTVFHMV GKDILRFHSI YWPILLMMLD VKLPDRLIAH 300
GWFVMKDGKM SKSKGNVVYP EMLVERYGLD PLRYYLMRNL PVGSDGTFTP 350
EDYVGRINYE LANDLGNLLN RTVSMINKYF DGQIPAYVEG VTEFDHVLAE 400
VAEQSIADFH THMEAVDYPR ALEAVWTLIS RTNKYIDETA PWVLAKDEAL 450
RDQLASVMSH LAASIRVVAH LIEPFMMETS RAVLTQLGLE EVSSLENLSL 500
ADFPADVTVV AKGTPIFPRL NMEEEIAYIK EQMEGNKPAV EKEWNPDAVE 550
LKLNKDEIKF EDFDKVEIRV AEVKEVSKVE GSDKLLQFRL DAGDGEDRQI 600
LSGIAKYYPN EQELVGKKVQ IVANLKPRKM MKKYVSQGMI LSAEHDGKLT 650
LLTVDPAVPN GSVIG 665
Length:665
Mass (Da):75,593
Last modified:May 26, 2009 - v1
Checksum:iDFAB60A1CC4AB91B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000918 Genomic DNA. Translation: ACO16256.1.
RefSeqiYP_002740106.1. NC_012468.1.

Genome annotation databases

EnsemblBacteriaiACO16256; ACO16256; SP70585_0831.
GeneIDi7684253.
KEGGisnm:SP70585_0831.
PATRICi19667978. VBIStrPne83895_0856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000918 Genomic DNA. Translation: ACO16256.1 .
RefSeqi YP_002740106.1. NC_012468.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 488221.SP70585_0831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO16256 ; ACO16256 ; SP70585_0831 .
GeneIDi 7684253.
KEGGi snm:SP70585_0831.
PATRICi 19667978. VBIStrPne83895_0856.

Phylogenomic databases

eggNOGi COG0143.
HOGENOMi HOG000200401.
KOi K01874.
OMAi HPEFVQP.
OrthoDBi EOG6CVV9B.

Enzyme and pathway databases

BioCyci SPNE488221:GH4U-816-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
2.40.50.140. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_01228. Met_tRNA_synth_type2.
InterProi IPR004495. Met-tRNA-synth_Ia_bsu_C.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR012340. NA-bd_OB-fold.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002547. tRNA-bd_dom.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
TIGR00399. metG_C_term. 1 hit.
PROSITEi PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Streptococcus pneumoniae strain 70585."
    Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70585.

Entry informationi

Entry nameiC1C6D0_STRP7
AccessioniPrimary (citable) accession number: C1C6D0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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