Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C1C673 (THIM2_STRP7) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 2

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name=TH kinase 2
Short name=Thz kinase 2
Gene names
Name:thiM2
Ordered Locus Names:SP70585_0771
OrganismStreptococcus pneumoniae (strain 70585) [Complete proteome] [HAMAP]
Taxonomic identifier488221 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Hydroxyethylthiazole kinase 2 HAMAP-Rule MF_00228
PRO_0000383897

Sites

Binding site411Substrate; via amide nitrogen By similarity
Binding site1161ATP By similarity
Binding site1661ATP By similarity
Binding site1931Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
C1C673 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 106E1B8F78228346

FASTA26729,182
        10         20         30         40         50         60 
MQEFTNPFPI GSSSLIHCMT NEISCEMLAN GILALGCKPV MADDPREVLD FTKQSQALFI 

        70         80         90        100        110        120 
NLGHLSAEKE KAIRMAASYA NQSSLPMVVD AVGVTTSSIR KSLVKDLLDY RPTVIKGNMS 

       130        140        150        160        170        180 
EIRSLVGLKH HGVGVDASAK DQETEDLLQV LKDWCQTYPG MSFLVTGPKD LVVSKNQVAV 

       190        200        210        220        230        240 
LENGCTELDW ITGTGDLVGA LTAVFLSQGK TGFEASCLAV SYLNIAAEKI VVQGMGLEEF 

       250        260 
RYQVLNQLSL LRRDENWLDT IKGEVYE 

« Hide

References

[1]"Complete genome sequence of Streptococcus pneumoniae strain 70585."
Hotopp J.D., Censini S., Masignani V., Covacci A., Tettelin H.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 70585.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000918 Genomic DNA. Translation: ACO16608.1.
RefSeqYP_002740049.1. NC_012468.1.

3D structure databases

ProteinModelPortalC1C673.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING488221.SP70585_0771.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO16608; ACO16608; SP70585_0771.
GeneID7683153.
KEGGsnm:SP70585_0771.
PATRIC19667854. VBIStrPne83895_0794.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMALPLMATH.
OrthoDBEOG628F8M.
ProtClustDBCLSK559900.

Enzyme and pathway databases

BioCycSPNE488221:GH4U-757-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM2_STRP7
AccessionPrimary (citable) accession number: C1C673
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways