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Protein

UvrABC system protein C

Gene

uvrC

Organism
Streptococcus pneumoniae (strain 70585)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:SP70585_0679
OrganismiStreptococcus pneumoniae (strain 70585)
Taxonomic identifieri488221 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002211 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002006021 – 614UvrABC system protein CAdd BLAST614

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

SMRiC1C5Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 91GIY-YIGUniRule annotationAdd BLAST78
Domaini196 – 231UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279960.
KOiK03703.
OMAiLFPIRQC.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

C1C5Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLIKSKLE LLPTSPGCYI HKDKNGTIIY VGKAKNLRNR VRSYFRGSHD
60 70 80 90 100
TKTEALVSEI VDFEFIVTES NIEALLLEIN LIKENKPKYN IMLKDDKSYP
110 120 130 140 150
FIKITNERYP RLIITRQVKK DGGLYFGPYP DVGAANEIKR LLDRIFPFRK
160 170 180 190 200
CTNPPSKVCF YYHIGQCMAH TICKKDEAYF KSMAQEVSDF LKGHDDKIID
210 220 230 240 250
DLKSKMAVAA QSMEFERAAE YRDLIQAIGT LRTKQRVMAK DLQNRDVFGY
260 270 280 290 300
YVDKGWMCVQ VFFVRQGKLI ERDVNLFPYF NDPDEDFLTY VGQFYQEKSH
310 320 330 340 350
LVPNEVLIPQ DIDEEAVKAL VDSKILKPQR GEKKQLVNLA IKNARVSLEQ
360 370 380 390 400
KFNLLEKSVE KTQGAIENLG RLLQIPTPVR IESFDNSNIM GTSPVSAMVV
410 420 430 440 450
FVNGKPSKKD YRKYKIKTVV GPDDYASMRE VIRRRYGRVQ REALTPPDLI
460 470 480 490 500
VIDGGQGQVN IAKQVIQEEL GLDIPIAGLQ KNDKHQTHEL LFGDPLEVVD
510 520 530 540 550
LSRNSQEFFL LQRIQDEAHR FAITFHRQLR SKNSFSSQLD GIDGLGPKRK
560 570 580 590 600
QNLMKHFKSL TKIKEASVDE IVEVGVPRVV AEAVQRKLNP QGEALPQVAE
610
ERVDYQTEGN HNKP
Length:614
Mass (Da):70,389
Last modified:May 26, 2009 - v1
Checksum:i0FDF268B66BBAAE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000918 Genomic DNA. Translation: ACO16335.1.
RefSeqiWP_001061118.1. NC_012468.1.

Genome annotation databases

EnsemblBacteriaiACO16335; ACO16335; SP70585_0679.
KEGGisnm:SP70585_0679.

Similar proteinsi

Entry informationi

Entry nameiUVRC_STRP7
AccessioniPrimary (citable) accession number: C1C5Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families