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Protein
Submitted name:

LP16188p

Gene

Rpt4-RA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
LP16188pImported
Gene namesi
Name:Rpt4-RAImported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Subcellular locationi

PTM / Processingi

Proteomic databases

PeptideAtlasiC1C3F8
PRIDEiC1C3F8

Expressioni

Gene expression databases

BgeeiFBgn0028685
ExpressionAtlasiC1C3F8 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiC1C3F8, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 322AAAInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 70Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0651 Eukaryota
COG1222 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035263 PSMC6
PANTHERiPTHR23073:SF59 PTHR23073:SF59, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Fragment.

C1C3F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KVQRKSSNKM TVTATPMPDN LRVKALSEYR KKLLEHKEIE GRLKEKREEI
60 70 80 90 100
KDLTKLYDKS ENDLKALQSV GQIVGEVLKQ LTEDKFIVKA TNGPRYVVGC
110 120 130 140 150
RRQLDKAKLK SGTRVALDMT TLTIMRYLPR EVDPLVYNMS HEDPGDVTYS
160 170 180 190 200
AIGGLTDQIR ELREVIELPL LNPELFLRVG ITPPKGCLLY GPPGTGKTLL
210 220 230 240 250
ARAVASQLDA NFLKVVSSAI VDKYIGESAR LIREMFNYAR DHQPCIIFMD
260 270 280 290 300
EIDAIGGRRF SEGTSADREI QRTLMELLNQ MDGFDSLGQV KMIMATNRPD
310 320 330 340 350
TLDPALLRPG RLDRKIEIPL PNEQARLEIL KIHALKIAKH GEIDYEAIVK
360 370 380 390 400
LSDNFNGADL RNVCTEAGLF AIRAEREYVI QEDFMKAVRK VSDNKKLESK

LDYKPV
Length:406
Mass (Da):45,967
Last modified:May 26, 2009 - v1
Checksum:i2DE99F5C50BC3916
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT081387 mRNA Translation: ACO51518.1

Genome annotation databases

EnsemblMetazoaiFBtr0305495; FBpp0293948; FBgn0028685

Similar proteinsi

Entry informationi

Entry nameiC1C3F8_DROME
AccessioniPrimary (citable) accession number: C1C3F8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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