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Protein

Acetaldehyde dehydrogenase 6

Gene

ROP_pROB02-02250

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Acyl-thioester intermediateUniRule annotation1
Binding sitei297NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18NADUniRule annotation4
Nucleotide bindingi164 – 172NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 6UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 6UniRule annotation
Gene namesi
Ordered Locus Names:ROP_pROB02-02250
Encoded oniPlasmid pROB020 Publication
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Plasmid pROB02

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877251 – 327Acetaldehyde dehydrogenase 6Add BLAST327

Structurei

3D structure databases

ProteinModelPortaliC1BE29
SMRiC1BE29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiMIKVIRH
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

C1BE29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENTRKVTV AVIGSGNIGT DLMIKVIRHS DVLQMGAMVG IDPDSDGLAR
60 70 80 90 100
ARRLGVPTTA VGVHGLLELP NFDEIDVVFD ATSAKAHAAN AALLEPLGKR
110 120 130 140 150
LIDLTPAALG PFVVPAVNLD EHRHAANVNM VTCGGQATIP IVAAVSRVTP
160 170 180 190 200
VAYAEIVASI ASKSAGPGTR ANIDEFTETT SHAIETVGGA RRGKAIIVLN
210 220 230 240 250
PADPPLIMRD TVLCLISARD PATHDAIRNS IQAMVEHVAT YVPGYRLKQQ
260 270 280 290 300
VQITPVPDGQ PVHTLLASGD TAAPTHQVSV FLEVEGAAHY LPAYAGNLDI
310 320
MTSAAVRYAE SVADTIAAPA ATQGATR
Length:327
Mass (Da):34,054
Last modified:May 26, 2009 - v1
Checksum:iF0DAF5DDEA10DE2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011117 Genomic DNA Translation: BAH47232.1
RefSeqiWP_012687258.1, NC_012521.1

Genome annotation databases

EnsemblBacteriaiBAH47232; BAH47232; ROP_pROB02-02250
KEGGirop:ROP_pROB02-02250
PATRICifig|632772.20.peg.8609

Similar proteinsi

Entry informationi

Entry nameiACDH6_RHOOB
AccessioniPrimary (citable) accession number: C1BE29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome
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Main funding by: National Institutes of Health