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C1BE29

- ACDH6_RHOOB

UniProt

C1BE29 - ACDH6_RHOOB

Protein

Acetaldehyde dehydrogenase 6

Gene

ROP_pROB02-02250

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
    Binding sitei297 – 2971NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 184NADUniRule annotation
    Nucleotide bindingi164 – 1729NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-8126-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 6UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 6UniRule annotation
    Gene namesi
    Ordered Locus Names:ROP_pROB02-02250
    Encoded oniPlasmid pROB020 Publication
    OrganismiRhodococcus opacus (strain B4)
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Plasmid pROB02

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Acetaldehyde dehydrogenase 6PRO_0000387725Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliC1BE29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiFTETTAH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1BE29-1 [UniParc]FASTAAdd to Basket

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    MSENTRKVTV AVIGSGNIGT DLMIKVIRHS DVLQMGAMVG IDPDSDGLAR    50
    ARRLGVPTTA VGVHGLLELP NFDEIDVVFD ATSAKAHAAN AALLEPLGKR 100
    LIDLTPAALG PFVVPAVNLD EHRHAANVNM VTCGGQATIP IVAAVSRVTP 150
    VAYAEIVASI ASKSAGPGTR ANIDEFTETT SHAIETVGGA RRGKAIIVLN 200
    PADPPLIMRD TVLCLISARD PATHDAIRNS IQAMVEHVAT YVPGYRLKQQ 250
    VQITPVPDGQ PVHTLLASGD TAAPTHQVSV FLEVEGAAHY LPAYAGNLDI 300
    MTSAAVRYAE SVADTIAAPA ATQGATR 327
    Length:327
    Mass (Da):34,054
    Last modified:May 26, 2009 - v1
    Checksum:iF0DAF5DDEA10DE2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011117 Genomic DNA. Translation: BAH47232.1.
    RefSeqiWP_012687258.1. NC_012521.1.
    YP_002777169.1. NC_012521.1.

    Genome annotation databases

    EnsemblBacteriaiBAH47232; BAH47232; ROP_pROB02-02250.
    GeneIDi7737218.
    KEGGirop:ROP_pROB02-02250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011117 Genomic DNA. Translation: BAH47232.1 .
    RefSeqi WP_012687258.1. NC_012521.1.
    YP_002777169.1. NC_012521.1.

    3D structure databases

    ProteinModelPortali C1BE29.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH47232 ; BAH47232 ; ROP_pROB02-02250 .
    GeneIDi 7737218.
    KEGGi rop:ROP_pROB02-02250.

    Phylogenomic databases

    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi FTETTAH.

    Enzyme and pathway databases

    BioCyci ROPA632772:GH0Q-8126-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4.

    Entry informationi

    Entry nameiACDH6_RHOOB
    AccessioniPrimary (citable) accession number: C1BE29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3