Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C1B8H9

- ACDH2_RHOOB

UniProt

C1B8H9 - ACDH2_RHOOB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetaldehyde dehydrogenase 2

Gene

ROP_37350

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
Binding sitei266 – 2661NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 144NADUniRule annotation
Nucleotide bindingi157 – 1659NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-3760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
Gene namesi
Ordered Locus Names:ROP_37350
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002212: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Acetaldehyde dehydrogenase 2PRO_0000387721Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_37350.

Structurei

3D structure databases

ProteinModelPortaliC1B8H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
OMAiQPELPDF.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1B8H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRKSAAIIG SGNIGTDLMY KLLRSEHIEP RYMVGIDPDS EGLARARQEG
60 70 80 90 100
LEASAGGLDW LLAQPELPDF VFEATSAKIH AAAAPRYADA GITAIDLTPA
110 120 130 140 150
SVGPYVVPAV NLDAHLGAPN VNMVSCAGQA TIPILYAINE VADASYGEIV
160 170 180 190 200
AAIASHSAGP GTRQNLSEFS EKTGKALAQV AGADRAKAIS VINPAEPPMN
210 220 230 240 250
MRDTVYAKVR NPDPAAIEKA VIDMVAKVQQ YVPGYSLRLV DVDGDLVTVM
260 270 280 290
LEVVGAGDFL PTYAGNLDII TAAAVQVADV MAQQNLVQGA AQ
Length:292
Mass (Da):30,451
Last modified:May 26, 2009 - v1
Checksum:iDF4216303E902CD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH51982.1.
RefSeqiWP_012690921.1. NC_012522.1.
YP_002780927.1. NC_012522.1.

Genome annotation databases

EnsemblBacteriaiBAH51982; BAH51982; ROP_37350.
GeneIDi7746947.
KEGGirop:ROP_37350.
PATRICi23224761. VBIRhoOpa21106_3770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH51982.1 .
RefSeqi WP_012690921.1. NC_012522.1.
YP_002780927.1. NC_012522.1.

3D structure databases

ProteinModelPortali C1B8H9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 632772.ROP_37350.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH51982 ; BAH51982 ; ROP_37350 .
GeneIDi 7746947.
KEGGi rop:ROP_37350.
PATRICi 23224761. VBIRhoOpa21106_3770.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
OMAi QPELPDF.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci ROPA632772:GH0Q-3760-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4.

Entry informationi

Entry nameiACDH2_RHOOB
AccessioniPrimary (citable) accession number: C1B8H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3