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C1B7U1 (C1B7U1_RHOOB) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897
Gene names
Name:gyrA HAMAP MF_01897 EMBL BAH51744.1
Ordered Locus Names:ROP_34970
OrganismRhodococcus opacus (strain B4) [Complete proteome] [HAMAP]
Taxonomic identifier632772 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length840 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897

Subcellular location

Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Sequences

Sequence LengthMass (Da)Tools
C1B7U1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: F545ED488E8D6F48

FASTA84092,883
        10         20         30         40         50         60 
MTDTTLPPEG PGHDRIEPVD IQQEMQSSYI DYAMSVIVGR ALPDVRDGLK PVHRRVLYAM 

        70         80         90        100        110        120 
YDNGYRPDRG YVKSARPVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSR 

       130        140        150        160        170        180 
GNDGAAAMRY TECRLTPLAM EMLREIDHET VDFTPNYDGR TQEPSVLPSR IPNLLINGSG 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLREVAE AIYWALENWE ADEESTLTAV MERVKGPDFP THGLIVGGQG 

       250        260        270        280        290        300 
IHDAYTTGRG SVRMRGVVEI EEDAKGRTTI VITELPYQVN PDNLITSIAE QVRDAKIAGI 

       310        320        330        340        350        360 
SDIHDESSDR AGMRIVVTVK RDAVAKVVLN NLYKHTQLQT SFGCNMLSIV DGVPRTLRLD 

       370        380        390        400        410        420 
QMIRLYVAHQ VEVIRRRTEY LLRKAEERAH ILRGLVKALD ALDEVIALIR ASQTVDIARA 

       430        440        450        460        470        480 
GLIELLTVDE IQADAILAMQ LRRLAALERQ KIIDELAEIE REIADLKDIL EKPERQRRIV 

       490        500        510        520        530        540 
RDELKEIVDK HGDDRRTRII AADGDVADED LIAREDVVVT ITETGYAKRT KTDLYRSQKR 

       550        560        570        580        590        600 
GGKGVQGAGL KQDDIVSHFF VSSTHDWLLF FTTKGRVYRA KAYELPEASR TARGQHVANL 

       610        620        630        640        650        660 
LAFQPDERIQ SVIQIKTYED APYLVLATRN GLVKKSKLTD FDSNRSGGIV AINLRGEDEL 

       670        680        690        700        710        720 
VGAVLCSSDD DLLLVSAQGQ SIRFSATDEA LRPMGRATSG VQGMRFNGDD ELLSLNVVRE 

       730        740        750        760        770        780 
GTYLLVATSG GYSKRTGMED YPVQGRGGKG VLTIQYDKKR GTLVGALIVN DDDELYAITS 

       790        800        810        820        830        840 
GGGVIRTAAK QVRKAGRQTK GVRLMNLGEG DNLLAIARNA DEPDETDDNA ESSGKGAKES

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References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011115 Genomic DNA. Translation: BAH51744.1.
RefSeqYP_002780689.1. NC_012522.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC1B7U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7746729.
GenomeReviewsGene locus ROP_34970 in contig AP011115_GR.
KEGGrop:ROP_34970.
PATRIC23224291. VBIRhoOpa21106_3538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMATGRGRIY.
ProtClustDBPRK05560.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit.
G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1B7U1_RHOOB
AccessionPrimary (citable) accession number: C1B7U1
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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