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Protein

Acetaldehyde dehydrogenase 1

Gene

cmtH

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Acyl-thioester intermediateUniRule annotation1
Binding sitei292NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Name:cmtH
Ordered Locus Names:ROP_34170
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877201 – 321Acetaldehyde dehydrogenase 1Add BLAST321

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_34170

Structurei

3D structure databases

ProteinModelPortaliC1B7L1
SMRiC1B7L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiIMMHNTI
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

C1B7L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKINVAII GSGNIGTDLM IKVLRNSDIL EMGAMVGIDP NSDGLARAAR
60 70 80 90 100
LNVPTTADGV QGLIGLDNFA AIDIVFDATS AGAHRSNAAA LAPYGKKLVD
110 120 130 140 150
LTPASIGPYV VPPVNLEQHL DGDVDNVNMV TCGGQATIPM VAAISAVTPV
160 170 180 190 200
AYAEIVASIA SKSAGPGTRA NIDEFTETTS HAIEQVGGAA RGKAIIVLNP
210 220 230 240 250
AEPPLLMRDT VLALIGDADH DAIRASITGM AARVAEYVPG YRLKQDVQFT
260 270 280 290 300
AIPDGEPVHT LLPDGTGPVT TKVSVFLEVE GAAHYLPAYA GNLDIMTSAA
310 320
LRTAESIARR IQNTIPAEVA P
Length:321
Mass (Da):33,161
Last modified:May 26, 2009 - v1
Checksum:i42458B52BEA055AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA Translation: BAH51664.1
RefSeqiWP_012690614.1, NC_012522.1

Genome annotation databases

EnsemblBacteriaiBAH51664; BAH51664; ROP_34170
KEGGirop:ROP_34170
PATRICifig|632772.20.peg.3581

Similar proteinsi

Entry informationi

Entry nameiACDH1_RHOOB
AccessioniPrimary (citable) accession number: C1B7L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health