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C1B7L1

- ACDH1_RHOOB

UniProt

C1B7L1 - ACDH1_RHOOB

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Protein
Acetaldehyde dehydrogenase 1
Gene
cmtH, ROP_34170
Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei292 – 2921NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NAD By similarity
Nucleotide bindingi163 – 1719NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-3443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene namesi
Name:cmtH
Ordered Locus Names:ROP_34170
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002212: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Acetaldehyde dehydrogenase 1UniRule annotation
PRO_0000387720Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_34170.

Structurei

3D structure databases

ProteinModelPortaliC1B7L1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiRRIQNTI.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

C1B7L1-1 [UniParc]FASTAAdd to Basket

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MTDKINVAII GSGNIGTDLM IKVLRNSDIL EMGAMVGIDP NSDGLARAAR    50
LNVPTTADGV QGLIGLDNFA AIDIVFDATS AGAHRSNAAA LAPYGKKLVD 100
LTPASIGPYV VPPVNLEQHL DGDVDNVNMV TCGGQATIPM VAAISAVTPV 150
AYAEIVASIA SKSAGPGTRA NIDEFTETTS HAIEQVGGAA RGKAIIVLNP 200
AEPPLLMRDT VLALIGDADH DAIRASITGM AARVAEYVPG YRLKQDVQFT 250
AIPDGEPVHT LLPDGTGPVT TKVSVFLEVE GAAHYLPAYA GNLDIMTSAA 300
LRTAESIARR IQNTIPAEVA P 321
Length:321
Mass (Da):33,161
Last modified:May 26, 2009 - v1
Checksum:i42458B52BEA055AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH51664.1.
RefSeqiWP_012690614.1. NC_012522.1.
YP_002780609.1. NC_012522.1.

Genome annotation databases

EnsemblBacteriaiBAH51664; BAH51664; ROP_34170.
GeneIDi7741389.
KEGGirop:ROP_34170.
PATRICi23224129. VBIRhoOpa21106_3457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH51664.1 .
RefSeqi WP_012690614.1. NC_012522.1.
YP_002780609.1. NC_012522.1.

3D structure databases

ProteinModelPortali C1B7L1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 632772.ROP_34170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH51664 ; BAH51664 ; ROP_34170 .
GeneIDi 7741389.
KEGGi rop:ROP_34170.
PATRICi 23224129. VBIRhoOpa21106_3457.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi RRIQNTI.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci ROPA632772:GH0Q-3443-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4.

Entry informationi

Entry nameiACDH1_RHOOB
AccessioniPrimary (citable) accession number: C1B7L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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