C1B7L1 (ACDH1_RHOOB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Name:	cmtH
Ordered Locus Names:	ROP_34170

Organism

Rhodococcus opacus (strain B4) [Complete proteome] [HAMAP]

Taxonomic identifier

632772 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Acetaldehyde dehydrogenase 1 HAMAP MF_01657		PRO_0000387720
Regions
	Nucleotide binding	12 – 15	4	NAD By similarity
	Nucleotide binding	163 – 171	9	NAD By similarity
Sites
	Binding site	292	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1B7L1 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 42458B52BEA055AE	FASTA	321	33,161
	10 20 30 40 50 60 MTDKINVAII GSGNIGTDLM IKVLRNSDIL EMGAMVGIDP NSDGLARAAR LNVPTTADGV 70 80 90 100 110 120 QGLIGLDNFA AIDIVFDATS AGAHRSNAAA LAPYGKKLVD LTPASIGPYV VPPVNLEQHL 130 140 150 160 170 180 DGDVDNVNMV TCGGQATIPM VAAISAVTPV AYAEIVASIA SKSAGPGTRA NIDEFTETTS 190 200 210 220 230 240 HAIEQVGGAA RGKAIIVLNP AEPPLLMRDT VLALIGDADH DAIRASITGM AARVAEYVPG 250 260 270 280 290 300 YRLKQDVQFT AIPDGEPVHT LLPDGTGPVT TKVSVFLEVE GAAHYLPAYA GNLDIMTSAA 310 320 LRTAESIARR IQNTIPAEVA P

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP011115 Genomic DNA. Translation: BAH51664.1.
RefSeq	YP_002780609.1. NC_012522.1.
3D structure databases
ProteinModelPortal	C1B7L1.
ModBase	Search...
Protein-protein interaction databases
STRING	C1B7L1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7741389.
GenomeReviews	Gene locus ROP_34170 in contig AP011115_GR.
KEGG	rop:ROP_34170.
PATRIC	23224129. VBIRhoOpa21106_3457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_RHOOB

Accession

Primary (citable) accession number: C1B7L1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program