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C1B4A1 (DCUP_RHOOB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:ROP_68430
OrganismRhodococcus opacus (strain B4) [Complete proteome] [HAMAP]
Taxonomic identifier632772 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000197536

Regions

Region36 – 405Substrate binding By similarity

Sites

Binding site851Substrate By similarity
Binding site1601Substrate By similarity
Binding site2151Substrate By similarity
Binding site3341Substrate By similarity
Site851Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
C1B4A1 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 7AEC44CCC2C06DE2

FASTA35537,336
        10         20         30         40         50         60 
MSERATYAAR RVLPDAPLLA AAEGRAPGRR PVWFMRQAGR SLPEYREIRS GIGMLESCFD 

        70         80         90        100        110        120 
PALVCEITMQ PVRRHGVDAA ILFSDIVVPL KAAGIDLDIV AGTGPVVANP VRSIADVAAL 

       130        140        150        160        170        180 
PRLVPEEVGA VAQAVQLLTA ELGSTPLIGF AGAPFTLASY LVEGGPSRNH ERTKALMHSD 

       190        200        210        220        230        240 
PKTWHALLGT LADTTITFLQ AQLRAGVDAI QLFDSWAGAL SLAEYREFVL PHSERVFAEV 

       250        260        270        280        290        300 
ESAKVPRIHF GVGTGELLGA MGEAGADVVG VDWRIPLDVA ARRVGPGKAL QGNLDPAVLF 

       310        320        330        340        350 
AGSAAVEKQV RRITAEADAA LAAGATGHIF NLGHGVLPDT DPGALTALVE LVHSL

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011115 Genomic DNA. Translation: BAH55090.1.
RefSeqYP_002784035.1. NC_012522.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC1B4A1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7745479.
GenomeReviewsGene locus ROP_68430 in contig AP011115_GR.
KEGGrop:ROP_68430.
PATRIC23231127. VBIRhoOpa21106_6928.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_RHOOB
AccessionPrimary (citable) accession number: C1B4A1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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