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C1B486

- C1B486_RHOOB

UniProt

C1B486 - C1B486_RHOOB

Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Rhodococcus opacus (strain B4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotationSAAS annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotationSAAS annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei89 – 891Thiamine pyrophosphateUniRule annotation
    Metal bindingi161 – 1611MagnesiumUniRule annotation
    Metal bindingi191 – 1911MagnesiumUniRule annotation
    Binding sitei191 – 1911Thiamine pyrophosphateUniRule annotation
    Binding sitei302 – 3021Thiamine pyrophosphateUniRule annotation
    Binding sitei383 – 3831Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotationSAAS annotation, Thiamine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-6878-MONOMER.
    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthaseUniRule annotation
    Gene namesi
    Name:dxsUniRule annotationImported
    Ordered Locus Names:ROP_68280Imported
    OrganismiRhodococcus opacus (strain B4)Imported
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi632772.ROP_68280.

    Structurei

    3D structure databases

    ProteinModelPortaliC1B486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 1323Thiamine pyrophosphate bindingUniRule annotation
    Regioni162 – 1632Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    HOGENOMiHOG000012986.
    KOiK01662.
    OMAiRINAGDP.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1B486-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEARKAACI TEGAISLGVL ARIQTPDDLR QLNPAEMKQL AAEIREFLVQ    50
    KVAATGGHLG PNLGVVELTL ALHRIFESPA DPIVFDTGHQ AYVHKILTGR 100
    KDDFDSLRKQ GGLSGYPCRA ESDHDWVESS HASAALSYAD GLAKAFELTG 150
    QARHVVAVVG DGALTGGMCW EALNNIAAGK DRSVVIVVND NGRSYAPTIG 200
    GLADHLAALR LQPGYERILD SGRRMVKKLP WVGRTAYSVL HGMKAGLKDA 250
    VAPQVMFTDL GIKYLGPVDG HDEAALESAL RRAKAFGGPV IVHAVTRKGM 300
    GYAPAENHVA DQMHSTGVID PVTGKSAGSA SADWTSVFSA ELIDQASHRQ 350
    DIVAITAAMA GPTGLAAFGE KYPDRMFDVG IAEQHAVTSA AGLALGGLHP 400
    VVAVYSTFLN RAFDQLLMDV ALLKLPVTLV LDRAGITGSD GASHNGMWDM 450
    SLLGIVPGMR VAAPRDTATL REELAEALAV DDGPTALRFP KGTVGDDVPA 500
    VSRLDGVVDI LHAPSGRNDV LIVSVGAFAG LALAAAERLE QQGISATVVD 550
    PRWVLPVPES LLKLAEDSTM VVTVEDSGLH GGVGSTVSAA LRAAGVDVPC 600
    RDLGVPQRFL DHASRAQIHA ELGLTAQDVA RQITGWFAGL GNLRPGQQNG 650
    VVADLDAQRA ENRGQ 665
    Length:665
    Mass (Da):69,831
    Last modified:May 26, 2009 - v1
    Checksum:iE0A94A32A2152E0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH55075.1.
    RefSeqiYP_002784020.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH55075; BAH55075; ROP_68280.
    GeneIDi7741621.
    KEGGirop:ROP_68280.
    PATRICi23231095. VBIRhoOpa21106_6912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH55075.1 .
    RefSeqi YP_002784020.1. NC_012522.1.

    3D structure databases

    ProteinModelPortali C1B486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_68280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH55075 ; BAH55075 ; ROP_68280 .
    GeneIDi 7741621.
    KEGGi rop:ROP_68280.
    PATRICi 23231095. VBIRhoOpa21106_6912.

    Phylogenomic databases

    eggNOGi COG1154.
    HOGENOMi HOG000012986.
    KOi K01662.
    OMAi RINAGDP.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .
    BioCyci ROPA632772:GH0Q-6878-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4Imported.

    Entry informationi

    Entry nameiC1B486_RHOOB
    AccessioniPrimary (citable) accession number: C1B486
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3