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C1B313

- IF2_RHOOB

UniProt

C1B313 - IF2_RHOOB

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Protein

Translation initiation factor IF-2

Gene
infB, ROP_66830
Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4868GTP By similarity
Nucleotide bindingi529 – 5335GTP By similarity
Nucleotide bindingi583 – 5864GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-6733-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:ROP_66830
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002212: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974Translation initiation factor IF-2UniRule annotationPRO_1000118771Add
BLAST

Proteomic databases

PRIDEiC1B313.

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_66830.

Structurei

3D structure databases

ProteinModelPortaliC1B313.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini470 – 641172tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni479 – 4868G1 By similarity
Regioni504 – 5085G2 By similarity
Regioni529 – 5324G3 By similarity
Regioni583 – 5864G4 By similarity
Regioni619 – 6213G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1B313-1 [UniParc]FASTAAdd to Basket

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MAGKARVHEL AKELGVTSKE LLATLKEQGE FVKSASSTVE APVARRLRES    50
FPSAKSADSA ARPAAKPGAP APSTPATSAK PGGPRPGPKP AAPAPAAPAA 100
AAPAATPAAQ APAPAAPAAS TATPAAPASN APKPGRPTPA APAPAAPAAP 150
AAPAAASTPA APSTGAKPGG PRPGPKPPRV GNNPYSSAPA ERPAPRPAPG 200
APRPGAPRPA PGQGGPRPAP GQGGPRPAPG QGGPRPAPGQ GGPRPAPGQG 250
GPRPSPGSMP PRPNPGAMPA RSARPAPGGR PGRPGGAPGG RPGGGGGGYR 300
GGGAPGAGAG APGGGAPAGG FRGRPGGGGR PGQRGAAAGA FGRPGGAPRR 350
GRKSKRQKRQ EYDSMQAPAV GGVRLPRGNG ETIRLARGAS LSDFAEKIDA 400
NPAALVQALF NLGEMVTATQ SVNDETLELL GGEMNYVVQV VSPEDEDREL 450
LDSFDLTYGE DEGGEEDLES RPPVVTVMGH VDHGKTRLLD TIRKANVREG 500
EAGGITQHIG AYQVLTELDG NERLVTFIDT PGHEAFTAMR ARGAKATDLA 550
ILVVAADDGV MPQTVEAINH AQAADVPIVV AVNKIDKEGA NPDKIRQQLT 600
EYGLVAEEYG GDTMFVDISA KQGTNIDALL EAVLLTADAA LDLRANPDMD 650
AQGVAIEAHL DRGRGPVATV LIQRGTLRVG DSIVAGDAYG RVRRMVDEHG 700
DDVLEAMPSR PVQVVGFTSV PGAGDNLLVV DEDRIARQIA DRRNARKRNA 750
LAAKSRKRIS LEDLDSALKE TSQLNLILKG DNSGTVEALE EALHGIEIDD 800
EVQLRVIDRG VGGVTETNVN LAAASNAIII GFNVRAEGKA TELANREGVD 850
IRYYSVIYQA IDEVEKALKG MLKPIYEEVE LGKAEIRAMF RSSKVGNIAG 900
CLVTSGTIRR NAKARLLRDN TVVAETVTIS SLKREKEDAV EVREGYECGL 950
TLTYSDIKVG DVIEAYELRE KPRD 974
Length:974
Mass (Da):100,063
Last modified:May 26, 2009 - v1
Checksum:i82E392A60C241398
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH54930.1.
RefSeqiWP_015890368.1. NC_012522.1.
YP_002783875.1. NC_012522.1.

Genome annotation databases

EnsemblBacteriaiBAH54930; BAH54930; ROP_66830.
GeneIDi7745365.
KEGGirop:ROP_66830.
PATRICi23230799. VBIRhoOpa21106_6764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH54930.1 .
RefSeqi WP_015890368.1. NC_012522.1.
YP_002783875.1. NC_012522.1.

3D structure databases

ProteinModelPortali C1B313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 632772.ROP_66830.

Proteomic databases

PRIDEi C1B313.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH54930 ; BAH54930 ; ROP_66830 .
GeneIDi 7745365.
KEGGi rop:ROP_66830.
PATRICi 23230799. VBIRhoOpa21106_6764.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci ROPA632772:GH0Q-6733-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4.

Entry informationi

Entry nameiIF2_RHOOB
AccessioniPrimary (citable) accession number: C1B313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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