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C1B313

- IF2_RHOOB

UniProt

C1B313 - IF2_RHOOB

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi479 – 4868GTPUniRule annotation
    Nucleotide bindingi529 – 5335GTPUniRule annotation
    Nucleotide bindingi583 – 5864GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-6733-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:ROP_66830
    OrganismiRhodococcus opacus (strain B4)
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974Translation initiation factor IF-2PRO_1000118771Add
    BLAST

    Proteomic databases

    PRIDEiC1B313.

    Interactioni

    Protein-protein interaction databases

    STRINGi632772.ROP_66830.

    Structurei

    3D structure databases

    ProteinModelPortaliC1B313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini470 – 641172tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni479 – 4868G1By similarity
    Regioni504 – 5085G2By similarity
    Regioni529 – 5324G3By similarity
    Regioni583 – 5864G4By similarity
    Regioni619 – 6213G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNPDMDAQ.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1B313-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGKARVHEL AKELGVTSKE LLATLKEQGE FVKSASSTVE APVARRLRES    50
    FPSAKSADSA ARPAAKPGAP APSTPATSAK PGGPRPGPKP AAPAPAAPAA 100
    AAPAATPAAQ APAPAAPAAS TATPAAPASN APKPGRPTPA APAPAAPAAP 150
    AAPAAASTPA APSTGAKPGG PRPGPKPPRV GNNPYSSAPA ERPAPRPAPG 200
    APRPGAPRPA PGQGGPRPAP GQGGPRPAPG QGGPRPAPGQ GGPRPAPGQG 250
    GPRPSPGSMP PRPNPGAMPA RSARPAPGGR PGRPGGAPGG RPGGGGGGYR 300
    GGGAPGAGAG APGGGAPAGG FRGRPGGGGR PGQRGAAAGA FGRPGGAPRR 350
    GRKSKRQKRQ EYDSMQAPAV GGVRLPRGNG ETIRLARGAS LSDFAEKIDA 400
    NPAALVQALF NLGEMVTATQ SVNDETLELL GGEMNYVVQV VSPEDEDREL 450
    LDSFDLTYGE DEGGEEDLES RPPVVTVMGH VDHGKTRLLD TIRKANVREG 500
    EAGGITQHIG AYQVLTELDG NERLVTFIDT PGHEAFTAMR ARGAKATDLA 550
    ILVVAADDGV MPQTVEAINH AQAADVPIVV AVNKIDKEGA NPDKIRQQLT 600
    EYGLVAEEYG GDTMFVDISA KQGTNIDALL EAVLLTADAA LDLRANPDMD 650
    AQGVAIEAHL DRGRGPVATV LIQRGTLRVG DSIVAGDAYG RVRRMVDEHG 700
    DDVLEAMPSR PVQVVGFTSV PGAGDNLLVV DEDRIARQIA DRRNARKRNA 750
    LAAKSRKRIS LEDLDSALKE TSQLNLILKG DNSGTVEALE EALHGIEIDD 800
    EVQLRVIDRG VGGVTETNVN LAAASNAIII GFNVRAEGKA TELANREGVD 850
    IRYYSVIYQA IDEVEKALKG MLKPIYEEVE LGKAEIRAMF RSSKVGNIAG 900
    CLVTSGTIRR NAKARLLRDN TVVAETVTIS SLKREKEDAV EVREGYECGL 950
    TLTYSDIKVG DVIEAYELRE KPRD 974
    Length:974
    Mass (Da):100,063
    Last modified:May 26, 2009 - v1
    Checksum:i82E392A60C241398
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54930.1.
    RefSeqiWP_015890368.1. NC_012522.1.
    YP_002783875.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH54930; BAH54930; ROP_66830.
    GeneIDi7745365.
    KEGGirop:ROP_66830.
    PATRICi23230799. VBIRhoOpa21106_6764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54930.1 .
    RefSeqi WP_015890368.1. NC_012522.1.
    YP_002783875.1. NC_012522.1.

    3D structure databases

    ProteinModelPortali C1B313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_66830.

    Proteomic databases

    PRIDEi C1B313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH54930 ; BAH54930 ; ROP_66830 .
    GeneIDi 7745365.
    KEGGi rop:ROP_66830.
    PATRICi 23230799. VBIRhoOpa21106_6764.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NPDMDAQ.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci ROPA632772:GH0Q-6733-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4.

    Entry informationi

    Entry nameiIF2_RHOOB
    AccessioniPrimary (citable) accession number: C1B313
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3