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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi479 – 486GTPUniRule annotation8
Nucleotide bindingi529 – 533GTPUniRule annotation5
Nucleotide bindingi583 – 586GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:ROP_66830
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001187711 – 974Translation initiation factor IF-2Add BLAST974

Proteomic databases

PRIDEiC1B313.

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_66830.

Structurei

3D structure databases

ProteinModelPortaliC1B313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini470 – 641tr-type GAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni479 – 486G1By similarity8
Regioni504 – 508G2By similarity5
Regioni529 – 532G3By similarity4
Regioni583 – 586G4By similarity4
Regioni619 – 621G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiGGTQGAF.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1B313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKARVHEL AKELGVTSKE LLATLKEQGE FVKSASSTVE APVARRLRES
60 70 80 90 100
FPSAKSADSA ARPAAKPGAP APSTPATSAK PGGPRPGPKP AAPAPAAPAA
110 120 130 140 150
AAPAATPAAQ APAPAAPAAS TATPAAPASN APKPGRPTPA APAPAAPAAP
160 170 180 190 200
AAPAAASTPA APSTGAKPGG PRPGPKPPRV GNNPYSSAPA ERPAPRPAPG
210 220 230 240 250
APRPGAPRPA PGQGGPRPAP GQGGPRPAPG QGGPRPAPGQ GGPRPAPGQG
260 270 280 290 300
GPRPSPGSMP PRPNPGAMPA RSARPAPGGR PGRPGGAPGG RPGGGGGGYR
310 320 330 340 350
GGGAPGAGAG APGGGAPAGG FRGRPGGGGR PGQRGAAAGA FGRPGGAPRR
360 370 380 390 400
GRKSKRQKRQ EYDSMQAPAV GGVRLPRGNG ETIRLARGAS LSDFAEKIDA
410 420 430 440 450
NPAALVQALF NLGEMVTATQ SVNDETLELL GGEMNYVVQV VSPEDEDREL
460 470 480 490 500
LDSFDLTYGE DEGGEEDLES RPPVVTVMGH VDHGKTRLLD TIRKANVREG
510 520 530 540 550
EAGGITQHIG AYQVLTELDG NERLVTFIDT PGHEAFTAMR ARGAKATDLA
560 570 580 590 600
ILVVAADDGV MPQTVEAINH AQAADVPIVV AVNKIDKEGA NPDKIRQQLT
610 620 630 640 650
EYGLVAEEYG GDTMFVDISA KQGTNIDALL EAVLLTADAA LDLRANPDMD
660 670 680 690 700
AQGVAIEAHL DRGRGPVATV LIQRGTLRVG DSIVAGDAYG RVRRMVDEHG
710 720 730 740 750
DDVLEAMPSR PVQVVGFTSV PGAGDNLLVV DEDRIARQIA DRRNARKRNA
760 770 780 790 800
LAAKSRKRIS LEDLDSALKE TSQLNLILKG DNSGTVEALE EALHGIEIDD
810 820 830 840 850
EVQLRVIDRG VGGVTETNVN LAAASNAIII GFNVRAEGKA TELANREGVD
860 870 880 890 900
IRYYSVIYQA IDEVEKALKG MLKPIYEEVE LGKAEIRAMF RSSKVGNIAG
910 920 930 940 950
CLVTSGTIRR NAKARLLRDN TVVAETVTIS SLKREKEDAV EVREGYECGL
960 970
TLTYSDIKVG DVIEAYELRE KPRD
Length:974
Mass (Da):100,063
Last modified:May 26, 2009 - v1
Checksum:i82E392A60C241398
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH54930.1.

Genome annotation databases

EnsemblBacteriaiBAH54930; BAH54930; ROP_66830.
KEGGirop:ROP_66830.
PATRICi23230799. VBIRhoOpa21106_6764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH54930.1.

3D structure databases

ProteinModelPortaliC1B313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi632772.ROP_66830.

Proteomic databases

PRIDEiC1B313.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH54930; BAH54930; ROP_66830.
KEGGirop:ROP_66830.
PATRICi23230799. VBIRhoOpa21106_6764.

Phylogenomic databases

eggNOGiENOG4107QHU. Bacteria.
COG0532. LUCA.
HOGENOMiHOG000076906.
KOiK02519.
OMAiGGTQGAF.
OrthoDBiPOG091H00EY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2_RHOOB
AccessioniPrimary (citable) accession number: C1B313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.