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C1B2V2 (C1B2V2_RHOOB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183 EMBL BAH54869.1
Ordered Locus Names:ROP_66220
OrganismRhodococcus opacus (strain B4) [Complete proteome] [HAMAP]
Taxonomic identifier632772 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 4130NADP By similarity HAMAP MF_00183

Sites

Metal binding1461Divalent metal cation By similarity HAMAP MF_00183
Metal binding1481Divalent metal cation By similarity HAMAP MF_00183
Metal binding2171Divalent metal cation By similarity HAMAP MF_00183
Binding site1231Substrate By similarity HAMAP MF_00183
Binding site1481Substrate By similarity HAMAP MF_00183
Binding site1721Substrate By similarity HAMAP MF_00183
Binding site1951Substrate By similarity HAMAP MF_00183
Binding site2171Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
C1B2V2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: ABA1556789EB4336

FASTA38539,681
        10         20         30         40         50         60 
MDETRPTRVL LLGSTGSIGT QALEVVAANP DKFTVVGLAA GGGNVELLGR QLHETGVSSV 

        70         80         90        100        110        120 
AVADPQAAAS LDLPGVLSGP GAVTELVRTT EADVVLNALV GSLGLEPTLA ALESGARLAL 

       130        140        150        160        170        180 
ANKESLVAGG PLVTAAAAPG QIVPVDSEHS ALAQCLRGGG ADEVDRLVLT ASGGPFRGWT 

       190        200        210        220        230        240 
ADRLESVTPE QAGAHPTWSM GPMNTLNSAT LVNKGLELIE THLLFGVDYD RIDVTVHPQS 

       250        260        270        280        290        300 
IVHSMVTFTD GSTLAQASPP DMKLPIALAL GWPHRVAGAA AACDFTTAST WEFEPLDSQV 

       310        320        330        340        350        360 
FPAVDLAREA GKGGGCLTAV YNAANEVAAQ AFLDGIIRFP RIVRTVASVL SEADEWSAPP 

       370        380 
ATVEDVLAAD GWARERARQL VKQEG

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP011115 Genomic DNA. Translation: BAH54869.1.
RefSeqYP_002783814.1. NC_012522.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC1B2V2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7745316.
GenomeReviewsGene locus ROP_66220 in contig AP011115_GR.
KEGGrop:ROP_66220.
PATRIC23230677. VBIRhoOpa21106_6703.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1B2V2_RHOOB
AccessionPrimary (citable) accession number: C1B2V2
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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