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C1B1D6

- C1B1D6_RHOOB

UniProt

C1B1D6 - C1B1D6_RHOOB

Protein

Thymidylate kinase

Gene

tmk

Organism
Rhodococcus opacus (strain B4)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-6430-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotationImported
    Ordered Locus Names:ROP_63840Imported
    OrganismiRhodococcus opacus (strain B4)Imported
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi632772.ROP_63840.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0125.
    HOGENOMiHOG000229076.
    KOiK00943.
    OMAiFPRYEQS.
    OrthoDBiEOG6ZH2MB.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1B1D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTLIALEGL DGAGKRTLVG AVVDRLTERG LTVGTLDFPR YGRSVHADLA    50
    SEALKGAHGD LAESVHAMAV MFALDRSGAV GELSDLLAGH DLVILDRYVA 100
    SNAAYGAARL HQAADGEFVG WVENLEFERL GLPRPDLQLY LDVPVALAAQ 150
    RARGRESADA SRSLDAYERD RGLQERTGEV YRELAVKDWM SPWWVLTPDT 200
    DPVTLAENLA LLSDDTARRD EKEHGTP 227
    Length:227
    Mass (Da):24,662
    Last modified:May 26, 2009 - v1
    Checksum:i99E1C2B00970BFB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54631.1.
    RefSeqiWP_015890087.1. NC_012522.1.
    YP_002783576.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH54631; BAH54631; ROP_63840.
    GeneIDi7741258.
    KEGGirop:ROP_63840.
    PATRICi23230181. VBIRhoOpa21106_6459.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54631.1 .
    RefSeqi WP_015890087.1. NC_012522.1.
    YP_002783576.1. NC_012522.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_63840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH54631 ; BAH54631 ; ROP_63840 .
    GeneIDi 7741258.
    KEGGi rop:ROP_63840.
    PATRICi 23230181. VBIRhoOpa21106_6459.

    Phylogenomic databases

    eggNOGi COG0125.
    HOGENOMi HOG000229076.
    KOi K00943.
    OMAi FPRYEQS.
    OrthoDBi EOG6ZH2MB.

    Enzyme and pathway databases

    BioCyci ROPA632772:GH0Q-6430-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4Imported.

    Entry informationi

    Entry nameiC1B1D6_RHOOB
    AccessioniPrimary (citable) accession number: C1B1D6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3