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Protein

Thymidylate kinase

Gene

tmk

Organism
Rhodococcus opacus (strain B4)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-6430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotationImported
Ordered Locus Names:ROP_63840Imported
OrganismiRhodococcus opacus (strain B4)Imported
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
ProteomesiUP000002212 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_63840.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229076.
KOiK00943.
OMAiFPRYGRS.
OrthoDBiEOG6ZH2MB.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

C1B1D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLIALEGL DGAGKRTLVG AVVDRLTERG LTVGTLDFPR YGRSVHADLA
60 70 80 90 100
SEALKGAHGD LAESVHAMAV MFALDRSGAV GELSDLLAGH DLVILDRYVA
110 120 130 140 150
SNAAYGAARL HQAADGEFVG WVENLEFERL GLPRPDLQLY LDVPVALAAQ
160 170 180 190 200
RARGRESADA SRSLDAYERD RGLQERTGEV YRELAVKDWM SPWWVLTPDT
210 220
DPVTLAENLA LLSDDTARRD EKEHGTP
Length:227
Mass (Da):24,662
Last modified:May 26, 2009 - v1
Checksum:i99E1C2B00970BFB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH54631.1.
RefSeqiWP_015890087.1. NC_012522.1.
YP_002783576.1. NC_012522.1.

Genome annotation databases

EnsemblBacteriaiBAH54631; BAH54631; ROP_63840.
KEGGirop:ROP_63840.
PATRICi23230181. VBIRhoOpa21106_6459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA. Translation: BAH54631.1.
RefSeqiWP_015890087.1. NC_012522.1.
YP_002783576.1. NC_012522.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi632772.ROP_63840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH54631; BAH54631; ROP_63840.
KEGGirop:ROP_63840.
PATRICi23230181. VBIRhoOpa21106_6459.

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229076.
KOiK00943.
OMAiFPRYGRS.
OrthoDBiEOG6ZH2MB.

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-6430-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4Imported.

Entry informationi

Entry nameiC1B1D6_RHOOB
AccessioniPrimary (citable) accession number: C1B1D6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 24, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.