Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Binding sitei101SubstrateUniRule annotation1
Binding sitei108NADUniRule annotation1
Binding sitei115NADUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Active sitei190Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 20NADUniRule annotation7
Nucleotide bindingi132 – 134NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:ROP_63030
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001850851 – 331Malate dehydrogenaseAdd BLAST331

Proteomic databases

PRIDEiC1B155

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_63030

Structurei

3D structure databases

ProteinModelPortaliC1B155
SMRiC1B155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D9Z Bacteria
COG0039 LUCA
HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

C1B155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSPTPAVV TVTGAAGSIG YAALFRIAAG AMLGPDTPIR LRLLEIPPAV
60 70 80 90 100
SAAEGTAMEL DDSAFPLLLD VEVHDDPKRG FDGTDVALLI GSRPRSKGME
110 120 130 140 150
RGDLLAANGQ IFTVQGRAIN QVAADGVRVL VVGNPANTNA LVAANNAPDV
160 170 180 190 200
PAERFTALTR LDHNRAIAQL ARHSGAAVRD ISRVTIWGNH SSTQYPDIFH
210 220 230 240 250
ARVGDRSGAD IAADREWLTG DFIPTVANRG SAIIEARGTS SAASAANAAI
260 270 280 290 300
DHVHDWVLGT PEGDWTSVAL PSTGAYGVPE GLVSSFPVRS VDGAWQVVEG
310 320 330
LEIDDFSRKR IDASVADLES ERDAVRGMGF I
Length:331
Mass (Da):34,717
Last modified:May 26, 2009 - v1
Checksum:i1CE88454C843AEAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA Translation: BAH54550.1
RefSeqiWP_015890008.1, NC_012522.1

Genome annotation databases

EnsemblBacteriaiBAH54550; BAH54550; ROP_63030
KEGGirop:ROP_63030
PATRICifig|632772.20.peg.6581

Similar proteinsi

Entry informationi

Entry nameiMDH_RHOOB
AccessioniPrimary (citable) accession number: C1B155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health