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C1B066

- C1B066_RHOOB

UniProt

C1B066 - C1B066_RHOOB

Protein

Alanine racemase

Gene

alr

Organism
Rhodococcus opacus (strain B4)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei156 – 1561SubstrateUniRule annotation
    Active sitei287 – 2871Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei335 – 3351Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-6286-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:ROP_62400Imported
    OrganismiRhodococcus opacus (strain B4)Imported
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi632772.ROP_62400.

    Structurei

    3D structure databases

    ProteinModelPortaliC1B066.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiGHTWTAQ.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1B066-1 [UniParc]FASTAAdd to Basket

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    MTLAEAVPAD DHGHSEPAAP AQAAAPQAEA VVDLDAIAHN VRILRDSARG    50
    AAMMAVVKAD GYNHGAVAVA RAALAAGASE LGVTTVSEAL TLRRAGIDAP 100
    VLAWLHTVDA DFAPAIAADV ELGVSSPRHL AAVVAAARRV GTPAIVTMKV 150
    DTGLNRNGVA PDELAQVLVD LARAQAEGSV RLRGIFSHLA HADEPHHAWI 200
    DSQRDRLVDA IADAKRHGLV PEVVHLSNSA ATLTRPDLRF DMVRPGIAIY 250
    GLSPVPELGQ FGLRPAMTLR SRVALVKKVA AGEGVSYGHQ WVAPRDTTVA 300
    LLPLGYADGL PRSLSGRFEV QLGAERRPGI GRVCMDQVVV DLGPDGGGVR 350
    EGDTAVFFGN GDLGEPIAQE WADKLDTIHY EVVTGVRGRT VRTYVGGTGT 400
    Length:400
    Mass (Da):41,837
    Last modified:May 26, 2009 - v1
    Checksum:iF3B90705D1A02D74
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54487.1.
    RefSeqiWP_015889950.1. NC_012522.1.
    YP_002783432.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH54487; BAH54487; ROP_62400.
    GeneIDi7742673.
    KEGGirop:ROP_62400.
    PATRICi23229879. VBIRhoOpa21106_6308.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH54487.1 .
    RefSeqi WP_015889950.1. NC_012522.1.
    YP_002783432.1. NC_012522.1.

    3D structure databases

    ProteinModelPortali C1B066.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_62400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH54487 ; BAH54487 ; ROP_62400 .
    GeneIDi 7742673.
    KEGGi rop:ROP_62400.
    PATRICi 23229879. VBIRhoOpa21106_6308.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi GHTWTAQ.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ROPA632772:GH0Q-6286-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4Imported.

    Entry informationi

    Entry nameiC1B066_RHOOB
    AccessioniPrimary (citable) accession number: C1B066
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3