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C1AX87

- DNLI_RHOOB

UniProt

C1AX87 - DNLI_RHOOB

Protein

Probable DNA ligase

Gene

lig

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei210 – 2101ATPUniRule annotation
    Active sitei212 – 2121N6-AMP-lysine intermediateUniRule annotation
    Binding sitei217 – 2171ATPUniRule annotation
    Binding sitei232 – 2321ATPUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei296 – 2961ATPUniRule annotation
    Binding sitei367 – 3671ATPUniRule annotation
    Binding sitei373 – 3731ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-1364-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:ROP_13440
    OrganismiRhodococcus opacus (strain B4)
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Probable DNA ligasePRO_1000134731Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi632772.ROP_13440.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiRKVKPVH.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1AX87-1 [UniParc]FASTAAdd to Basket

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    MLFSQIVATS RDVGATRSRK VKVATLREAL TRLEQAEVEP VVAWLSGELR    50
    QGRIGIGWRT VADIPATPAD VAAVTVSEVD GTISAVAEVS GSGSAARRRE 100
    LLADLFARTT ADERDFLLRL LTGDLRQGAL EGVMTDAIAA AADLPIEPVR 150
    RAFMLSGRLP ATAVAAFDGG VDALTAFRLE VGRPVRPMLA SPAESLADAW 200
    SELGGDVSVE YKLDGARIQV HRNGDEVRIF TRTLREITGS VPELVALVAR 250
    LPCTSAVFDG ETLALTDSGR PRPFQETMSR FGAESARDLL LHPYFFDCLH 300
    LDGVDLLDSP LEERLKALER VAPQHRIPGL IRPDSEGAAT HFDDALAAGH 350
    EGVMVKSLTA PYAAGRRGRA WQKVKPEHTL DLVVLGAEWG YGRRTGYLSN 400
    LHLGARDPDG GAPIMVGKTF KGLTDALLQW QTDEFPRHER ARDDHTVYLH 450
    PDLVVEIELD GVQVSTRYPG GLALRFARVL RYRPDKTAAD ADTIDAVRSL 500
    LPG 503
    Length:503
    Mass (Da):54,564
    Last modified:May 26, 2009 - v1
    Checksum:iE47CF1599977069D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH49591.1.
    RefSeqiYP_002778536.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH49591; BAH49591; ROP_13440.
    GeneIDi7747097.
    KEGGirop:ROP_13440.
    PATRICi23219891. VBIRhoOpa21106_1344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH49591.1 .
    RefSeqi YP_002778536.1. NC_012522.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_13440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH49591 ; BAH49591 ; ROP_13440 .
    GeneIDi 7747097.
    KEGGi rop:ROP_13440.
    PATRICi 23219891. VBIRhoOpa21106_1344.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi RKVKPVH.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci ROPA632772:GH0Q-1364-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4.

    Entry informationi

    Entry nameiDNLI_RHOOB
    AccessioniPrimary (citable) accession number: C1AX87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3