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Protein

Probable DNA ligase

Gene

lig

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1
Active sitei212N6-AMP-lysine intermediateUniRule annotation1
Binding sitei217ATPUniRule annotation1
Binding sitei232ATPUniRule annotation1
Binding sitei261ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei367ATPUniRule annotation1
Binding sitei373ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:ROP_13440
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001347311 – 503Probable DNA ligaseAdd BLAST503

Proteomic databases

PRIDEiC1AX87

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_13440

Structurei

3D structure databases

SMRiC1AX87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

C1AX87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFSQIVATS RDVGATRSRK VKVATLREAL TRLEQAEVEP VVAWLSGELR
60 70 80 90 100
QGRIGIGWRT VADIPATPAD VAAVTVSEVD GTISAVAEVS GSGSAARRRE
110 120 130 140 150
LLADLFARTT ADERDFLLRL LTGDLRQGAL EGVMTDAIAA AADLPIEPVR
160 170 180 190 200
RAFMLSGRLP ATAVAAFDGG VDALTAFRLE VGRPVRPMLA SPAESLADAW
210 220 230 240 250
SELGGDVSVE YKLDGARIQV HRNGDEVRIF TRTLREITGS VPELVALVAR
260 270 280 290 300
LPCTSAVFDG ETLALTDSGR PRPFQETMSR FGAESARDLL LHPYFFDCLH
310 320 330 340 350
LDGVDLLDSP LEERLKALER VAPQHRIPGL IRPDSEGAAT HFDDALAAGH
360 370 380 390 400
EGVMVKSLTA PYAAGRRGRA WQKVKPEHTL DLVVLGAEWG YGRRTGYLSN
410 420 430 440 450
LHLGARDPDG GAPIMVGKTF KGLTDALLQW QTDEFPRHER ARDDHTVYLH
460 470 480 490 500
PDLVVEIELD GVQVSTRYPG GLALRFARVL RYRPDKTAAD ADTIDAVRSL

LPG
Length:503
Mass (Da):54,564
Last modified:May 26, 2009 - v1
Checksum:iE47CF1599977069D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA Translation: BAH49591.1
RefSeqiWP_012688563.1, NC_012522.1

Genome annotation databases

EnsemblBacteriaiBAH49591; BAH49591; ROP_13440
KEGGirop:ROP_13440
PATRICifig|632772.20.peg.1417

Similar proteinsi

Entry informationi

Entry nameiDNLI_RHOOB
AccessioniPrimary (citable) accession number: C1AX87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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