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C1AX87 (DNLI_RHOOB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:ROP_13440
OrganismRhodococcus opacus (strain B4) [Complete proteome] [HAMAP]
Taxonomic identifier632772 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Probable DNA ligase HAMAP-Rule MF_00407
PRO_1000134731

Sites

Active site2121N6-AMP-lysine intermediate By similarity
Binding site2101ATP By similarity
Binding site2171ATP By similarity
Binding site2321ATP By similarity
Binding site2611ATP By similarity
Binding site2961ATP By similarity
Binding site3671ATP By similarity
Binding site3731ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C1AX87 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: E47CF1599977069D

FASTA50354,564
        10         20         30         40         50         60 
MLFSQIVATS RDVGATRSRK VKVATLREAL TRLEQAEVEP VVAWLSGELR QGRIGIGWRT 

        70         80         90        100        110        120 
VADIPATPAD VAAVTVSEVD GTISAVAEVS GSGSAARRRE LLADLFARTT ADERDFLLRL 

       130        140        150        160        170        180 
LTGDLRQGAL EGVMTDAIAA AADLPIEPVR RAFMLSGRLP ATAVAAFDGG VDALTAFRLE 

       190        200        210        220        230        240 
VGRPVRPMLA SPAESLADAW SELGGDVSVE YKLDGARIQV HRNGDEVRIF TRTLREITGS 

       250        260        270        280        290        300 
VPELVALVAR LPCTSAVFDG ETLALTDSGR PRPFQETMSR FGAESARDLL LHPYFFDCLH 

       310        320        330        340        350        360 
LDGVDLLDSP LEERLKALER VAPQHRIPGL IRPDSEGAAT HFDDALAAGH EGVMVKSLTA 

       370        380        390        400        410        420 
PYAAGRRGRA WQKVKPEHTL DLVVLGAEWG YGRRTGYLSN LHLGARDPDG GAPIMVGKTF 

       430        440        450        460        470        480 
KGLTDALLQW QTDEFPRHER ARDDHTVYLH PDLVVEIELD GVQVSTRYPG GLALRFARVL 

       490        500 
RYRPDKTAAD ADTIDAVRSL LPG 

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP011115 Genomic DNA. Translation: BAH49591.1.
RefSeqYP_002778536.1. NC_012522.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING632772.ROP_13440.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH49591; BAH49591; ROP_13440.
GeneID7747097.
KEGGrop:ROP_13440.
PATRIC23219891. VBIRhoOpa21106_1344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMARKVKPVH.
OrthoDBEOG6Q8HXT.

Enzyme and pathway databases

BioCycROPA632772:GH0Q-1364-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_RHOOB
AccessionPrimary (citable) accession number: C1AX87
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families