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C1ATZ5

- HIS8_RHOOB

UniProt

C1ATZ5 - HIS8_RHOOB

Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. histidinol-phosphate transaminase activity Source: UniProtKB-HAMAP
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciROPA632772:GH0Q-761-MONOMER.
    UniPathwayiUPA00031; UER00012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
    Alternative name(s):
    Imidazole acetol-phosphate transaminaseUniRule annotation
    Gene namesi
    Name:hisCUniRule annotation
    Ordered Locus Names:ROP_07560
    OrganismiRhodococcus opacus (strain B4)
    Taxonomic identifieri632772 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
    ProteomesiUP000002212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Histidinol-phosphate aminotransferasePRO_1000149110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei235 – 2351N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi632772.ROP_07560.

    Structurei

    3D structure databases

    ProteinModelPortaliC1ATZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0079.
    HOGENOMiHOG000288510.
    KOiK00817.
    OMAiYHLSVVT.
    OrthoDBiEOG651SWW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01023. HisC_aminotrans_2.
    InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01141. hisC. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1ATZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAANVPGSS IGVDALPIRE NLRGKSAYGA PQLTVPVQLN TNENPHPPTK    50
    ALVDDVAESV REAARELHRY PDRDAVALRT DLAAYLVRQT GVPVTVDNVW 100
    AANGSNEILQ QLLQAFGGPG RSAMGFVPSY SMHPIIADGT ETEWLPIFRR 150
    ADFALDVDAA TAAIAERRPD VVFVTSPNNP TGHSVGIAEL RRVLDSAPGI 200
    VIVDEAYAEF SDAPSALTLI DEYPSKLVVS RTMSKAFAFA GGRLGYLAAA 250
    PAFIEALLLV RLPYHLSVVT QAAARAALRH ANETLGSVHA LAAERVRVSK 300
    ALEDTGFHVI PSDANFILFG EFTDSARAWQ AYLDRGVLIR DVGIPGYLRA 350
    TVGLASENDA FIVASDEIAA TELTSSGDRG 380
    Length:380
    Mass (Da):40,522
    Last modified:May 26, 2009 - v1
    Checksum:i902DFD3E2900D9C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH49003.1.
    RefSeqiYP_002777948.1. NC_012522.1.

    Genome annotation databases

    EnsemblBacteriaiBAH49003; BAH49003; ROP_07560.
    GeneIDi7741688.
    KEGGirop:ROP_07560.
    PATRICi23218683. VBIRhoOpa21106_0754.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011115 Genomic DNA. Translation: BAH49003.1 .
    RefSeqi YP_002777948.1. NC_012522.1.

    3D structure databases

    ProteinModelPortali C1ATZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 632772.ROP_07560.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH49003 ; BAH49003 ; ROP_07560 .
    GeneIDi 7741688.
    KEGGi rop:ROP_07560.
    PATRICi 23218683. VBIRhoOpa21106_0754.

    Phylogenomic databases

    eggNOGi COG0079.
    HOGENOMi HOG000288510.
    KOi K00817.
    OMAi YHLSVVT.
    OrthoDBi EOG651SWW.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00012 .
    BioCyci ROPA632772:GH0Q-761-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01023. HisC_aminotrans_2.
    InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR005861. HisP_aminotrans.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01141. hisC. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
      Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4.

    Entry informationi

    Entry nameiHIS8_RHOOB
    AccessioniPrimary (citable) accession number: C1ATZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3