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C1ATZ5

- HIS8_RHOOB

UniProt

C1ATZ5 - HIS8_RHOOB

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Protein
Histidinol-phosphate aminotransferase
Gene
hisC, ROP_07560
Organism
Rhodococcus opacus (strain B4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. histidinol-phosphate transaminase activity Source: UniProtKB-HAMAP
  3. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciROPA632772:GH0Q-761-MONOMER.
UniPathwayiUPA00031; UER00012.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene namesi
Name:hisC
Ordered Locus Names:ROP_07560
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus
ProteomesiUP000002212: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Histidinol-phosphate aminotransferaseUniRule annotation
PRO_1000149110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi632772.ROP_07560.

Structurei

3D structure databases

ProteinModelPortaliC1ATZ5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0079.
HOGENOMiHOG000288510.
KOiK00817.
OMAiYHLSVVT.
OrthoDBiEOG651SWW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01023. HisC_aminotrans_2.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01141. hisC. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1ATZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MTAANVPGSS IGVDALPIRE NLRGKSAYGA PQLTVPVQLN TNENPHPPTK    50
ALVDDVAESV REAARELHRY PDRDAVALRT DLAAYLVRQT GVPVTVDNVW 100
AANGSNEILQ QLLQAFGGPG RSAMGFVPSY SMHPIIADGT ETEWLPIFRR 150
ADFALDVDAA TAAIAERRPD VVFVTSPNNP TGHSVGIAEL RRVLDSAPGI 200
VIVDEAYAEF SDAPSALTLI DEYPSKLVVS RTMSKAFAFA GGRLGYLAAA 250
PAFIEALLLV RLPYHLSVVT QAAARAALRH ANETLGSVHA LAAERVRVSK 300
ALEDTGFHVI PSDANFILFG EFTDSARAWQ AYLDRGVLIR DVGIPGYLRA 350
TVGLASENDA FIVASDEIAA TELTSSGDRG 380
Length:380
Mass (Da):40,522
Last modified:May 26, 2009 - v1
Checksum:i902DFD3E2900D9C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH49003.1.
RefSeqiYP_002777948.1. NC_012522.1.

Genome annotation databases

EnsemblBacteriaiBAH49003; BAH49003; ROP_07560.
GeneIDi7741688.
KEGGirop:ROP_07560.
PATRICi23218683. VBIRhoOpa21106_0754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011115 Genomic DNA. Translation: BAH49003.1 .
RefSeqi YP_002777948.1. NC_012522.1.

3D structure databases

ProteinModelPortali C1ATZ5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 632772.ROP_07560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH49003 ; BAH49003 ; ROP_07560 .
GeneIDi 7741688.
KEGGi rop:ROP_07560.
PATRICi 23218683. VBIRhoOpa21106_0754.

Phylogenomic databases

eggNOGi COG0079.
HOGENOMi HOG000288510.
KOi K00817.
OMAi YHLSVVT.
OrthoDBi EOG651SWW.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00012 .
BioCyci ROPA632772:GH0Q-761-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01023. HisC_aminotrans_2.
InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01141. hisC. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
    Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4.

Entry informationi

Entry nameiHIS8_RHOOB
AccessioniPrimary (citable) accession number: C1ATZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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