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C1ATZ5 (HIS8_RHOOB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase

EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:ROP_07560
OrganismRhodococcus opacus (strain B4) [Complete proteome] [HAMAP]
Taxonomic identifier632772 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeRhodococcus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01023

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01023

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
PRO_1000149110

Amino acid modifications

Modified residue2351N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C1ATZ5 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 902DFD3E2900D9C1

FASTA38040,522
        10         20         30         40         50         60 
MTAANVPGSS IGVDALPIRE NLRGKSAYGA PQLTVPVQLN TNENPHPPTK ALVDDVAESV 

        70         80         90        100        110        120 
REAARELHRY PDRDAVALRT DLAAYLVRQT GVPVTVDNVW AANGSNEILQ QLLQAFGGPG 

       130        140        150        160        170        180 
RSAMGFVPSY SMHPIIADGT ETEWLPIFRR ADFALDVDAA TAAIAERRPD VVFVTSPNNP 

       190        200        210        220        230        240 
TGHSVGIAEL RRVLDSAPGI VIVDEAYAEF SDAPSALTLI DEYPSKLVVS RTMSKAFAFA 

       250        260        270        280        290        300 
GGRLGYLAAA PAFIEALLLV RLPYHLSVVT QAAARAALRH ANETLGSVHA LAAERVRVSK 

       310        320        330        340        350        360 
ALEDTGFHVI PSDANFILFG EFTDSARAWQ AYLDRGVLIR DVGIPGYLRA TVGLASENDA 

       370        380 
FIVASDEIAA TELTSSGDRG 

« Hide

References

[1]"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4."
Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP011115 Genomic DNA. Translation: BAH49003.1.
RefSeqYP_002777948.1. NC_012522.1.

3D structure databases

ProteinModelPortalC1ATZ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING632772.ROP_07560.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH49003; BAH49003; ROP_07560.
GeneID7741688.
KEGGrop:ROP_07560.
PATRIC23218683. VBIRhoOpa21106_0754.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
HOGENOMHOG000288510.
KOK00817.
OMAIFEERTK.
OrthoDBEOG651SWW.
ProtClustDBPRK03317.

Enzyme and pathway databases

BioCycROPA632772:GH0Q-761-MONOMER.
UniPathwayUPA00031; UER00012.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01023. HisC_aminotrans_2.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01141. hisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_RHOOB
AccessionPrimary (citable) accession number: C1ATZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways