C1AT55 (TRPC_RHOOB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	ROP_07400

Organism

Rhodococcus opacus (strain B4) [Complete proteome] [HAMAP]

Taxonomic identifier

632772 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Rhodococcus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000198785

Sequences

	Sequence		Length	Mass (Da)
	C1AT55 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: A25119A39BCBBF1F	FASTA	269	27,541
	10 20 30 40 50 60 MTVLDSILDG VRADVAAREA VLDFAAVKAA AAAAPPALDA AAALLEPGIG VIAEVKRASP 70 80 90 100 110 120 SKGALADIAD PAELAAAYQA GGARVISVLT EERRFQGSLA DLDAVRRAVS IPILRKDFIV 130 140 150 160 170 180 GPYQIHEARA HGADMVLLIV AALEQDALAS LIDRTESLGM TALVEVHTEE EANRAIEAGA 190 200 210 220 230 240 KVIGVNARNL KTLEVDKNTF GEIAPGLPTE IIKIAESGVR GTADLLAYAG AGADAVLVGE 250 260 GLVTSGDPRK AVADLVNAGA HPSCPKPSR

References

[1]

"Comparison of the complete genome sequences of Rhodococcus erythropolis PR4 and Rhodococcus opacus B4." Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP011115 Genomic DNA. Translation: BAH48987.1.
RefSeq	YP_002777932.1. NC_012522.1.
3D structure databases
ProteinModelPortal	C1AT55.
ModBase	Search...
Protein-protein interaction databases
STRING	C1AT55.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7743899.
GenomeReviews	Gene locus ROP_07400 in contig AP011115_GR.
KEGG	rop:ROP_07400.
PATRIC	23218651. VBIRhoOpa21106_0738.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FFPEQVK.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_RHOOB

Accession

Primary (citable) accession number: C1AT55

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program