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Protein

NAD kinase

Gene

nadK

Organism
Rhodococcus opacus (strain B4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton acceptorUniRule annotation1
Binding sitei101NADUniRule annotation1
Binding sitei200NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 97NADUniRule annotation2
Nucleotide bindingi170 – 171NADUniRule annotation2
Nucleotide bindingi211 – 216NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:ROP_06680
OrganismiRhodococcus opacus (strain B4)
Taxonomic identifieri632772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus
Proteomesi
  • UP000002212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001335781 – 320NAD kinaseAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi632772.ROP_06680

Structurei

3D structure databases

SMRiC1ASY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227223
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

C1ASY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGSSGGQQ REREILLVAH PGRAEITETA RRVGKIFERA GIGMRVLVDE
60 70 80 90 100
VDSTRIEPMD GMAADEFLVP GLEVTIVQAG PDAALGCEMV LVLGGDGTFL
110 120 130 140 150
RAAELAQAAS IPVLGINLGR IGFLAETEAE HLDEALGQVV RREYRIEHRM
160 170 180 190 200
TLDVLVRVDD EIIERGWALN EASIENRSRL GVLEVVLEVD GRPVSAFGCD
210 220 230 240 250
GVLISTPTGS TAYAFSAGGP VVWPELEALL VVPSNAHALF ARPLVTSPES
260 270 280 290 300
LIAVETVAGS HDGLVFCDGR RTLELPAGAR VEVVRGKEPV RWVRLDSAPF
310 320
ADRMVRKFEL PVTGWRGRKP
Length:320
Mass (Da):34,458
Last modified:May 26, 2009 - v1
Checksum:i56EAFD812FCCEDE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011115 Genomic DNA Translation: BAH48915.1
RefSeqiWP_012687918.1, NC_012522.1

Genome annotation databases

EnsemblBacteriaiBAH48915; BAH48915; ROP_06680
KEGGirop:ROP_06680
PATRICifig|632772.20.peg.728

Similar proteinsi

Entry informationi

Entry nameiNADK_RHOOB
AccessioniPrimary (citable) accession number: C1ASY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health